Calcitonin Gene-related Peptide Receptor Antagonist

Calcitonin Gene-related Peptide Receptor Antagonists

Migraine with Aura

Migraine without Aura

<section class="Section" data-sectioncode="34089-3"><a name="ID_5F8FB1E3-3117-4E91-B8C4-C0160AF96229"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION </h1><p class="First">ZAVZPRET (zavegepant) nasal spray contains zavegepant hydrochloride, a calcitonin gene-related peptide receptor antagonist. Zavegepant hydrochloride is described chemically as (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl) piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl) piperidine-1-carboxamide hydrochloride and its structural formula is:</p><div class="Figure"><a name="id-25797725"></a><img alt="Chemical Structure" src="zavegepant-01.jpg"/></div><p>Its molecular formula is C<span class="Sub">36</span>H<span class="Sub">46</span>N<span class="Sub">8</span>O<span class="Sub">3</span>․HCl, representing a molecular weight of 675.28 g/mol. Zavegepant free base has a molecular weight of 638.82 g/mol. Zavegepant hydrochloride is a white to off-white powder, freely soluble in water, and has pKa values of 4.8 and 8.8. </p><p>Each unit-dose ZAVZPRET device for nasal administration delivers 10 mg of zavegepant (equivalent to 10.6 mg of zavegepant hydrochloride) in a buffered aqueous solution containing dextrose, hydrochloric acid, sodium hydroxide, and succinic acid in water for injection. The solution has a pH of 5.3 to 6.7.</p></section>

ZAVZPRET

zavegepant

zavegepant 10 MG Nasal Spray

Zavzpret

zavegepant 10 MG Nasal Spray [Zavzpret]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Zavzpret (zavegepant) is a nasal spray used to treat acute migraines in adults. It works as a calcitonin gene-related peptide (CGRP) receptor antagonist. The medication provides fast relief, with pain reduction beginning as early as 15 minutes after use. After 2 hours, it has shown to be more effective than a placebo in relieving symptoms like nausea, sensitivity to light (photophobia), and sensitivity to sound (phonophobia). It should be noted that Zavzpret is not intended for preventing migraines.