Compare drug alternatives

Rybelsus ® Alternatives

Rybelsus ®(semaglutide)
Synjardy®(metformin hydrochloride)
Prescription Only
Rybelsus tablets (semaglutide) are used by adults with type 2 diabetes to manage blood sugar levels. Taken once daily, Rybelsus is combined with diet and exercise. It boosts...
Prescription Only
Synjardy is a medication that combines empagliflozin and metformin, both of which are oral drugs designed to regulate blood sugar levels. Empagliflozin functions by assisting the...
Dosage & Administration
Oral. Learn more.
Oral . Learn more.
Start RYBELSUS® with 3 mg once daily for 30 days. The 3 mg dosage is intended for treatment initiation. •After 30 days on the 3 mg dosage, increase the dosage to 7 mg once daily. •The dosage may be increased to 14 mg.. Learn more.
Take orally twice daily with meals, with gradual dosage escalation to reduce the gastrointestinal side effects due to metformin.. Learn more.
Latin Shorthand
Initiate RYBELSUS® at 3 mg qd for 30 days. Then, escalate to 7 mg qd after 30 days. Consider up-titrating to 14 mg qd.. Learn more.
Take PO BID with meals, titrate dose gradually to mitigate metformin GI SE.. Learn more.
Financial Assistance
Out-Of-Pocket Costs With Copay Card
Annual Cap
$150 for a 1-month supply; $300 for a 2-month supply; $450 for a 3-month supply. Learn more.
$175 per month . Learn more.
Assistance Expiration
24 months. Learn more.
No lower-cost generic available
No lower-cost generic available
Physician Advisory
Adverse Reactions
Most common adverse reactions (incidence ≥5%) are nausea, abdominal pain, diarrhea, decreased appetite, vomiting and constipation.. Learn more.
Most common adverse reactions associated with empagliflozin (5% or greater incidence) were urinary tract infection and female genital mycotic infections. Most common adverse reactions associated with metformin (>5%) are diarrhea, nausea/vomiting, flatulence, abdominal discomfort, indigestion, asthenia, and headache.. Learn more.
Mechanism of Actions (MoA)
GLP-1 Receptor Agonists. Learn more.
SGLT2 Inhibitors. Learn more.
Special Populations
What is the risk of using RYBELSUS® during pregnancy?

The available data with RYBELSUS® use in pregnant women are insufficient to evaluate the drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes. Clinical considerations should be noted regarding the risks of poorly controlled diabetes during pregnancy.

How should RYBELSUS® be used during pregnancy?

RYBELSUS® should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

What animal reproduction studies have been conducted with RYBELSUS®?

In pregnant rats, embryofetal mortality, structural abnormalities, and alterations to growth occurred at maternal exposures below the maximum recommended human dose (MRHD) based on AUC. Similar findings were observed in rabbits and cynomolgus monkeys at exposures below the MRHD.

What is the estimated background risk of major birth defects and miscarriage?

The estimated background risk of major birth defects is 6–10% in women with pre-gestational diabetes with an HbA1c >7, and has been reported to be as high as 20–25% in women with a HbA1c >10. In the general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively.

What are the clinical considerations for poorly controlled diabetes during pregnancy?

Poorly controlled diabetes during pregnancy increases the maternal risk for diabetic ketoacidosis, pre-eclampsia, spontaneous abortions, preterm delivery, and delivery complications. It also increases the fetal risk for major birth defects, stillbirth, and macrosomia related morbidity.

Is there any information on RYBELSUS® use during lactation?

There are no data on the presence of semaglutide (active ingredient in RYBELSUS®) in human milk, its effects on the breastfed infant, or milk production. Semaglutide was detected in the milk of lactating rats. Due to species-specific differences, the clinical relevance of these data is not clear.

What should be considered regarding lactation and RYBELSUS®?

Breastfeeding is not recommended during treatment with RYBELSUS® due to potential accumulation of certain substances (such as SNAC) in breast milk. There are alternative formulations of semaglutide that can be used during lactation.

When should RYBELSUS® be discontinued in relation to a planned pregnancy?

RYBELSUS® should be discontinued in women at least 2 months before a planned pregnancy due to the long washout period for semaglutide.

Is RYBELSUS® safe for pediatric use?

The safety and effectiveness of RYBELSUS® have not been established in pediatric patients (younger than 18 years).

How is RYBELSUS® affected by renal impairment?

The safety and effectiveness of RYBELSUS® was evaluated in patients with moderate renal impairment, showing no clinically relevant change in semaglutide pharmacokinetics. No dose adjustment of RYBELSUS® is recommended for patients with renal impairment.

How is RYBELSUS® affected by hepatic impairment?

In subjects with different degrees of hepatic impairment, no clinically relevant change in semaglutide pharmacokinetics was observed. No dose adjustment of RYBELSUS® is recommended for patients with hepatic impairment.