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    • Compare Medications
    olumiant (baricitinib)More info
    rinvoq (upadacitinib)More info
    efficacy
    safety
    indications
    Coverage
    dosing
    pharmacology
    Savings
    efficacy
    ACR20 Response at Week 12
    cDMARD-IR: 66%; TNFi-IR: 49%
    cDMARD-IR: 64%; bDMARD-IR: 65%
    ACR50 Response at Week 12
    cDMARD-IR: 34%; TNFi-IR: 20%
    cDMARD-IR: 38%; bDMARD-IR: 34%
    DAS28-CRP <2.6 at Week 12
    cDMARD-IR: 26%; TNFi-IR: 11%
    cDMARD-IR: 31%; bDMARD-IR: 29%
    Review efficacy data to choose the clinically appropriate treatment for your patient
    safety
    Black Box Warning
    Yes
    Yes
    Contraindications
    None
    Known hypersensitivity to upadacitinib or excipients
    Most Common Adverse Reactions (≥1%)
    In RA: upper respiratory tract infection, nausea, herpes simplex, herpes zoster
    In RA: upper respiratory tract infection, herpes zoster, herpes simplex, bronchitis, nausea, cough, pyrexia, acne, headache
    indications
    Adult Rheumatoid Arthritis
    Yes
    Yes
    COVID-19 (hospitalized, requiring oxygen)
    Yes
    No
    Alopecia Areata
    Yes
    No
    Psoriatic Arthritis
    No
    Yes
    Ulcerative Colitis
    No
    Yes
    Crohn’s Disease
    No
    Yes
    Atopic Dermatitis
    No
    Yes
    Axial Spondyloarthritis / Ankylosing Spondylitis
    No
    Yes
    Juvenile Idiopathic Arthritis (Polyarticular, PsA, ERA)
    No
    Yes (≥2 years, weight-based dosing)
    Giant Cell Arteritis
    No
    Yes
    Coverage
    Add insurance carrier above to get more details about the coverage for each medication
    dosing
    Standard Dosing
    2 mg once daily orally, with or without food
    15 mg once daily (monotherapy or with cDMARDs)
    Renal Impairment Dosing
    Mild: 2 mg once daily; Moderate: 1 mg once daily; Severe: not recommended
    No adjustment needed (mild–severe)
    Hepatic Impairment Dosing
    Mild or Moderate: no adjustment; Severe: not recommended
    Mild or moderate: no adjustment; Severe: not recommended
    pharmacology
    Mechanism of Action
    JAK1/2 inhibitor with some TYK2 activity
    Selective JAK1 inhibitor
    Half-life
    12–16 hours
    8–14 hours
    Time to Peak
    1 hour
    2–4 hours (ER tablet)
    Bioavailability
    ~80%
    Not specified
    Savings
    Savings
    Coverage Not Required
    $25Olumiant (baricitinib)
    Learn more about this program
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    No data available
    Alternative Drug Suggestions