Analpram Hc

Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Topical corticosteroids are generally applied to the affected area as a thin film three to four times daily depending on the severity of the condition. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.

For cleansing the anogenital area, apply with a tissue or cotton ball.

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:

   Burning





   Hypertrichosis





   Maceration of the skin





   Itching





   Acneiform eruptions





   Secondary infection





   Irritation





   Hypopigmentation





   Skin atrophy





   Dryness





   Perioral dermatitis





   Striae





   Folliculitis





   Allergic contact dermatitis





   Miliaria

Topical corticosteroids are anti-inflammatory and anti-pruritic agents.  The structural formula, the chemical name, molecular formula and molecular weight for active ingredients are presented below:

hydrocortisone acetate





Pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11, 17-dihydroxy-, (11-beta)-





C



₂₃H



₃₂O



₆; mol. wt.: 404.50

pramoxine hydrochloride





4-(3-(p-butoxyphenoxy)propyl)morpholine hydrochloride





C



₁₇H



₂₇NO



₃.HCl ; mol. wt.: 329.87

Topical corticosteroids share anti-inflammatory, anti-pruritic and vasoconstrictive actions.

The mechanism of anti-inflammatory activity of topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.

Pramoxine hydrochloride is a topical anesthetic agent which provides temporary relief from itching and pain. It acts by stabilizing the neuronal membrane of nerve endings with which it comes into contact.