Asparagine-specific Enzyme

Precursor Cell Lymphoblastic Leukemia-Lymphoma

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-8"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Calaspargase pegol-mknl contains an asparagine specific enzyme derived from <span class="Italics">Escherichia coli</span>, as a conjugate of L-asparaginase (L-asparagine amidohydrolase) and monomethoxypolyethylene glycol (mPEG) with a succinimidyl carbonate (SC) linker. The SC linker is a chemically stable carbamate bond between the mPEG moiety and the lysine groups of L-asparaginase.</p><p>L-asparaginase is a tetrameric enzyme that is produced endogenously by <span class="Italics">E. coli</span> and consists of identical 34.5 kDa subunits. Approximately 31 to 39 molecules of SC-PEG are linked to L-asparaginase; the molecular weight of each SC-PEG molecule is about 5 kDa. The activity of ASPARLAS is expressed in units (U). </p><p>ASPARLAS injection is supplied as a clear, colorless, preservative-free, isotonic sterile solution in phosphate-buffered saline, pH 7.3 that requires dilution prior to intravenous infusion. Each vial of ASPARLAS contains 3,750 units in 5 mL of solution. Each milliliter contains 750 units of calaspargase pegol-mknl; dibasic sodium phosphate, USP (5.58 mg); monobasic sodium phosphate, USP (1.20 mg); and sodium chloride, USP (8.50 mg) in water for injection, USP.</p></section>

asparlas

calaspargase pegol

calaspargase pegol-mknl

5 ML calaspargase pegol-mknl 750 UNT/ML Injection

Asparlas

5 ML calaspargase pegol-mknl 750 UNT/ML Injection [Asparlas]

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