Barhemsys

BARHEMSYS^® is indicated in adults for:

• prevention of postoperative nausea and vomiting (PONV), either alone or in combination with an antiemetic of a different class.
• treatment of PONV in patients who have received antiemetic prophylaxis with an agent of a different class or have not received prophylaxis.

The recommended dosage of BARHEMSYS:

• Prevention of PONV, either alone or in combination with another antiemetic
  : 5 mg as a single intravenous dose infused over 1 to 2 minutes at the time of induction of anesthesia. (
  2.1 Recommended Dosage

  The recommended adult dosage of BARHEMSYS and infusion rate by indication is shown in the table below:

  Indication	Adult Dosage Regimen
  Prevention of PONV	5 mg as a single intravenous injection infused over 1 to 2 minutes at the time of induction of anesthesia [see Dosage and Administration (2.2)] .
  Treatment of PONV	10 mg as a single intravenous injection infused over 1 to 2 minutes in the event of nausea and/or vomiting after a surgical procedure [see Dosage and Administration (2.2)] .
  )
• Treatment of PONV
  : 10 mg as a single intravenous dose infused over 1 to 2 minutes in the event of nausea and/or vomiting after a surgical procedure. (
  2.1 Recommended Dosage

  The recommended adult dosage of BARHEMSYS and infusion rate by indication is shown in the table below:

  Indication	Adult Dosage Regimen
  Prevention of PONV	5 mg as a single intravenous injection infused over 1 to 2 minutes at the time of induction of anesthesia [see Dosage and Administration (2.2)] .
  Treatment of PONV	10 mg as a single intravenous injection infused over 1 to 2 minutes in the event of nausea and/or vomiting after a surgical procedure [see Dosage and Administration (2.2)] .
  )
• See full prescribing information for preparation and administration instructions
  . (
  2.2 Preparation and Administration

  • Dilution of BARHEMSYS is not required before administration. BARHEMSYS is chemically and physically compatible with Water for Injection, 5% Dextrose Injection, 0.9% Sodium Chloride Injection, and Lactated Ringer's Solution (also known as Ringer's Lactate Solution, Compound Sodium Lactate Solution, and Hartmann's Solution), any of which may be used to flush an intravenous line before or after administration of BARHEMSYS.
  • Protect from light. BARHEMSYS is subject to photodegradation. Administer BARHEMSYS within 12 hours of removal of the vial from the protective carton.
  • Prior to administration, inspect the BARHEMSYS solution visually for particulate matter and discoloration. Discard if particulate matter or discoloration is observed.
  )

Injection: 5 mg/2 mL (2.5 mg/mL) or 10 mg/4 mL (2.5 mg/mL) as a clear, colorless sterile solution in a single-dose vial.