Tyrosine Kinase Inhibitors

Kinase Inhibitor

Lymphoma, Mantle-Cell

<section class="Section" data-sectioncode="34089-3"><a name="ID_34c4e740-c60a-4653-b209-135e701735a5"></a><a name="section-9"></a><h1>11 DESCRIPTION </h1>CALQUENCE (acalabrutinib) is a kinase inhibitor. The molecular formula for acalabrutinib maleate is C26H23N7O2•C4H4O4.H2O, and the molecular weight is 599.59. The chemical name is 4-{8-Amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide (2Z)-2-butenedioic acid hydrate.The chemical structure of acalabrutinib is shown below:<div class="Figure"><a name="id2120331104"></a><img alt="chemical_structure" src="chemical_structure.jpg"/></div>Acalabrutinib maleate is a white to pale brown powder with pH-dependent solubility. It is freely soluble in water at pH values below 3 and practically insoluble at pH values above 6.CALQUENCE tablets are for oral administration. Each tablet contains 100 mg of acalabrutinib (equivalent to 129 mg of acalabrutinib maleate). Inactive ingredients in the tablet core are low-substituted hydroxypropyl cellulose, mannitol, microcrystalline cellulose, and sodium stearyl fumarate. The tablet coating consists of copovidone, ferric oxide yellow, ferric oxide red, hypromellose, medium-chain triglycerides, polyethylene glycol 3350, purified water and titanium dioxide.</section>

CALQUENCE

acalabrutinib

Calquence

acalabrutinib 100 MG Oral Tablet

acalabrutinib 100 MG Oral Tablet [Calquence]

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