Dosage & Administration Drug label Prior authorization Pharmacy Financial assistance

Carbaglu

(carglumic acid)

carglumic acid 200 MG Tablet for Oral Suspension [Carbaglu]

NO BLACK BOX WARNING

Dosage & administration

Acute Hyperammonemia due to NAGS deficiency

* The recommended pediatric and adult dosage is 100 mg/kg/day to 250 mg/kg/day divided into 2 to 4 doses and rounded to the nearest 100 mg.

Chronic Hyperammonemia due to NAGS deficiency

* The recommended pediatric and adult dosage is 10 mg/kg/day to 100 mg/kg/day divided into 2 to 4 doses and rounded to the nearest 100 mg.

Therapeutic Monitoring for NAGS Deficiency

* Closely monitor plasma ammonia and titrate dosage to maintain the ammonia level within normal range for the patient's age, taking into consideration their clinical condition.

Acute Hyperammonemia due to PA or MMA

* The recommended pediatric and adult dosage is:
* 150 mg/kg/day for patients less than or equal to 15 kg
* 3.3 g/m2/day for patients greater than 15 kg

* Divide the daily dosage into two equal doses and round up to the nearest 50 mg; administer each dose 12 hours apart.
* Continue treatment until ammonia level is less than 50 micromol/L and for a maximum duration of 7 days.

See Full Prescribing Information for Instructions on Dosage Adjustment in Patients with Renal Impairment

Preparation and Administration

* Disperse CARBAGLU tablets in water. Do not swallow whole or crushed.
* Take immediately before meals or feedings.
* For additional instructions on preparation and administration orally or through a nasogastric tube or gastrostomy tube, see Full Prescribing Information.

drug label

Carbaglu prescribing information

Contact Medical Science Liaison Report Adverse Event

prior authorization

Carbaglu prior authorization resources

PDFComplete Letter of Medical Necessity

PDFAppeals Tips & Checklist

PDFLetter of Medical Necessity: NAGS

Learn More

Benefits investigation

PDFCarbaglu Prescription & Enrollment Form

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pharmacy

Carbaglu preferred pharmacy

OTHERPharmacy List

financial assistance

Carbaglu financial assistance options

Co-pay savings program

commercial only

PDFCarbaglu Prescription & Enrollment Form

OTHEREnroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Foundation programs

under insured

no insurance

goverment insurance

65+

PDFCarbaglu Prescription & Enrollment Form

OTHERCarbaglu Patient Assistance Program

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Carbaglu patient education

Getting started on Carbaglu

BRAND PAGEInstructions For Use: NAGS Deficiency

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGEInstructions For Use: Propionic Acidemia (PA) and Methylmalonic Acidemia (MMA)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link

Patient toolkit

BRAND PAGEAbout Carbaglu

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHERView How to Take Carbaglu

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHERPatient Stories: NAGS

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHERPatient Resources

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Learn More

Other resources

Learn More

Carbaglu FAQs

How is the dosage of Carbaglu?Carbaglu is available in 1 dosages, including 200 mg Tab

What does Carbaglu treat?Carbaglu treats Hyperammonemia

What is Carbaglu made of?Carbaglu contains carglumic acid which is a Carbamoyl Phosphate Synthetase 1 Activator

How Is Carbaglu Administered?Carbaglu is administered as a Oral Suspension Tablet

What Are The Carbaglu Mechanism Of Action?Carbaglu mechanism of action is Carbamoyl Phosphate Synthetase 1 Activators

FAQ Data Source

Carbaglu

Dosage & administration

drug label

Carbaglu prescribing information

prior authorization

Carbaglu prior authorization resources

Benefits investigation

pharmacy

Carbaglu preferred pharmacy

financial assistance

Carbaglu financial assistance options

Co-pay savings program

Foundation programs

patient education

Carbaglu patient education

Getting started on Carbaglu

Patient toolkit

Other resources

people also ask

Carbaglu FAQs