Protein Kinase Inhibitors

Kinase Inhibitor

Carcinoma, Renal Cell

<section class="Section" data-sectioncode="34089-3"><a name="s11"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>COMETRIQ is the (S)-malate salt of cabozantinib, a kinase inhibitor. Cabozantinib (S)-malate is described chemically as N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N'-(4-fluorophenyl)cyclopropane- 1,1-dicarboxamide, (2S)-hydroxybutanedioate. The molecular formula is C28H24FN3O5•C4H6O5 and the molecular weight is 635.6 Daltons as malate salt. The chemical structure of cabozantinib (S)-malate salt is:<div class="Figure"><a name="m1"></a><img alt="image of chemical structure of COMETRIQ" src="cometriq-chem-structure.jpg"/></div>Cabozantinib (S)-malate salt is a white to off-white solid that is practically insoluble in aqueousmedia.COMETRIQ (cabozantinib) capsules for oral use are supplied as printed hard gelatin capsules containing cabozantinib (S)-malate equivalent to 20 mg or 80 mg cabozantinib and the following inactive ingredients: silicified microcrystalline cellulose, croscarmellose sodium, sodium starch glycolate, fumed silica, and stearic acid.The grey gelatin capsule shells contain black iron oxide and titanium dioxide and the Swedish orange gelatin capsule shells contain red iron oxide, and titanium dioxide. The printing ink contains shellac glaze, black iron oxide, N-butyl alcohol, isopropyl alcohol, propylene glycol, and ammonium hydroxide.</section>

COMETRIQ

cabozantinib

cabozantinib 20 MG Oral Capsule

Cometriq

cabozantinib 20 MG Oral Capsule [Cometriq]

cabozantinib 80 MG Oral Capsule

cabozantinib 80 MG Oral Capsule [Cometriq]

Psoriasis (PsO)

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Taltz

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Cosentyx

Siliq

Tremfya

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Stelara

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Verzenio

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