Dosage & Administration Efficacy safety testing Drug label Prior authorization Financial assistance

Cyramza

(ramucirumab)

10 ML ramucirumab 10 MG/ML Injection [Cyramza]50 ML ramucirumab 10 MG/ML Injection [Cyramza]

NO BLACK BOX WARNING

Dosage & administration

* For intravenous infusion only. Do not administer as an intravenous push or bolus.
* Premedicate before each infusion.
* Gastric Cancer: Administer CYRAMZA 8 mg/kg every 2 weeks as a single agent or in combination with weekly paclitaxel.
* Non-Small Cell Lung Cancer:
* Administer CYRAMZA 10 mg/kg every 2 weeks with daily erlotinib.
* Administer CYRAMZA 10 mg/kg on Day 1 of a 21-day cycle prior to docetaxel.

* Colorectal Cancer: Administer CYRAMZA 8 mg/kg every 2 weeks prior to FOLFIRI.
* Hepatocellular Carcinoma: Administer CYRAMZA 8 mg/kg every 2 weeks.

Cyramza clinical details

drug label

Cyramza prescribing information

Need to report a Cyramza issue?

ONLINE FORMReport adverse event

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prior authorization

Cyramza Prior authorization resources

NOT PROVIDED BY BRANDComplete Letter of Medical Necessity

Coverage Authorization Request

Coverage Authorization Appeals

Billing and Coding Guide

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Benefits investigation

NOT PROVIDED BY BRANDBenefits investigation resources

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Reimbursement help (FRM)

NOT PROVIDED BY BRANDReimbursement help (FRM) resources

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financial assistance

Cyramza Financial assistance options

Co-pay savings program

commercial only

Enroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

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Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

under insured

no insurance

goverment insurance

65+

Independent Patient Assistance Foundation Programs

Lilly Cares Foundation

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Cyramza Patient education