Depakote Prescribing & Dosing Schedule

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Depakote (divalproex sodium)

Depakote 125 MG Delayed Release Oral Tablet

Dosage & Administration

* Depakote is administered orally in divided doses. Depakote should be swallowed whole and should not be crushed or chewed .

* Mania: Initial dose is 750 mg daily, increasing as rapidly as possible to achieve therapeutic response or desired plasma level . The maximum recommended dosage is 60 mg/kg/day .

* Complex Partial Seizures: Start at 10 to 15 mg/kg/day, increasing at 1 week intervals by 5 to 10 mg/kg/day to achieve optimal clinical response; if response is not satisfactory, check valproate plasma level; see full prescribing information for conversion to monotherapy . The maximum recommended dosage is 60 mg/kg/day .

* Absence Seizures: Start at 15 mg/kg/day, increasing at 1 week intervals by 5 to 10 mg/kg/day until seizure control or limiting side effects . The maximum recommended dosage is 60 mg/kg/day .

* Migraine: The recommended starting dose is 250 mg twice daily, thereafter increasing to a maximum of 1,000 mg/day as needed .

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Depakote Prescribing Information

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financial assistance

Depakote Financial Assistance Options

Copay savings program

Enroll in Patient Savings Program

Mail Order Patients Savings Program (Rebate Form)

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form