Histamine H2 Receptor Antagonists

Histamine-2 Receptor Antagonist

Cyclooxygenase Inhibitors

Nonsteroidal Anti-inflammatory Drug

Arthritis, Juvenile

Arthritis, Rheumatoid

Bursitis

Duodenal Ulcer

Dysmenorrhea

Dyspepsia

Esophagitis, Peptic

Fever

Gastroesophageal Reflux

Gout

Heartburn

Inflammation

Menorrhagia

Osteoarthritis

Pain, Postoperative

Premenstrual Syndrome

Spondylitis, Ankylosing

Stomach Ulcer

Urticaria

Zollinger-Ellison Syndrome

Helicobacter Infections

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>DUEXIS (ibuprofen and famotidine) is supplied as a tablet for oral administration which combines the nonsteroidal anti- inflammatory drug, ibuprofen, and the histamine H2-receptor antagonist, famotidine.Ibuprofen is (±)-2-(p-isobutylphenyl)propionic acid. Its chemical formula is C13H18O2 and molecular weight is 206.28. Ibuprofen is a white powder that is very slightly soluble in water (&lt;1 mg/mL) and readily soluble in organic solvents such as ethanol and acetone. Its structural formula is:<img alt="Chemical Structure" src="duexis-01.jpg"/>Famotidine is N'-(aminosulfonyl)-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide. Its chemical formula is C8H15N7O2S3 and molecular weight is 337.45. Famotidine is a white to pale yellow crystalline compound that is freely soluble in glacial acetic acid, slightly soluble in methanol, very slightly soluble in water, and practically insoluble in ethanol. Its structural formula is:<img alt="Chemical Structure" src="duexis-02.jpg"/>Each DUEXIS tablet contains ibuprofen, USP (800 mg) and famotidine, USP (26.6 mg). The inactive ingredients in DUEXIS include: microcrystalline cellulose, anhydrous lactose, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, purified water, povidone, titanium dioxide, polyethylene glycol, polysorbate 80, polyvinyl alcohol, hypromellose, talc, FD&amp;C Blue #2/Indigo Carmine Aluminum Lake, and FD&amp;C Blue #1/Brilliant Blue FCF Aluminum Lake.</section>

DUEXIS

famotidine / ibuprofen

famotidine 26.6 MG / ibuprofen 800 MG Oral Tablet

Duexis

famotidine 26.6 MG / ibuprofen 800 MG Oral Tablet [Duexis]

famotidine

ibuprofen

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information

Medication Guide 

Pharmacy List 

Coverage Authorization Request 

Coverage Authorization Appeals 

Duexis PA Guide

Enroll in Patient Savings Program

FAQs: RA & Osteoarthritis

Instructions For Use: RA & Osteoarthritis 