<section class="Section" data-sectioncode="34089-3"><a name="section-10"></a><h1>11        DESCRIPTION</h1>Etanercept, a tumor necrosis factor (TNF) blocker, is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids and has an apparent molecular weight of approximately 150 kilodaltons. Enbrel (etanercept) Injection in the single-dose prefilled syringe and the single-dose prefilled SureClick autoinjector is clear and colorless, sterile, preservative-free solution, and is formulated at pH 6.3 ± 0.2. Enbrel (etanercept) for Injection is supplied in a multiple-dose vial as a sterile, white, preservative-free, lyophilized powder. Reconstitution with 1 mL of the supplied Sterile Bacteriostatic Water for Injection, USP (containing 0.9% benzyl alcohol) yields a multiple-dose, clear, and colorless solution 1 mL containing 25 mg of Enbrel, with a pH of 7.4 ± 0.3. Enbrel (etanercept) Injection in the Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector is clear and colorless, sterile, preservative-free solution, and is formulated at pH 6.3 ± 0.2.<table><col width="160"/><col width="200"/><col width="258"/><tbody class="Headless"><tr class="First"><td align="center" colspan="3">Table 5. Contents of Enbrel</td></tr><tr><td class="Lrule Rrule Toprule">Presentation</td><td class="Lrule Rrule Toprule">Active Ingredient Content</td><td class="Lrule Rrule Toprule">Inactive Ingredients Content</td></tr><tr><td class="Lrule Rrule Toprule">Enbrel 50 mg prefilled syringe and SureClick autoinjector</td><td class="Lrule Rrule Toprule">50 mg etanercept in 1 mL</td><td class="Lrule Rrule Toprule">25 mM L-arginine hydrochloride 120 mM sodium chloride 1% sucrose</td></tr><tr><td class="Lrule Rrule Toprule">Enbrel 25 mg prefilled syringe</td><td class="Lrule Rrule Toprule">25 mg etanercept in 0.5 mL</td><td class="Lrule Rrule Toprule">25 mM L-arginine hydrochloride 120 mM sodium chloride 1% sucrose</td></tr><tr><td class="Lrule Rrule Toprule">Enbrel 25 mg multiple-dose vial</td><td class="Lrule Rrule Toprule">After reconstitution, 25 mg etanercept in 1 mL</td><td class="Lrule Rrule Toprule">40 mg mannitol 10 mg sucrose 1.2 mg tromethamine</td></tr><tr class="Last"><td class="Lrule Rrule Toprule">Enbrel 50 mg Enbrel Mini single-dose prefilled cartridge for use with the AutoTouch reusable autoinjector only</td><td class="Lrule Rrule Toprule">50 mg etanercept in 1 mL</td><td class="Lrule Rrule Toprule">25 mM L-arginine hydrochloride 120 mM sodium chloride 1% sucrose</td></tr></tbody></table></section>

ENBREL

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio