Bipolar Disorder

Epilepsies, Partial

Phobic Disorders

Neuralgia, Postherpetic

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-11"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">HORIZANT (gabapentin enacarbil) is a prodrug of gabapentin. Gabapentin enacarbil is described as (1-{[({(1<span class="Italics">RS</span>)-1-[(2-Methylpropanoyl)oxy]ethoxy}carbonyl)amino]methyl} cyclohexyl) acetic acid. It has a molecular formula of C<span class="Sub">16</span>H<span class="Sub">27</span>NO<span class="Sub">6</span> and a molecular weight of 329.39. It is a racemate and has the following structural formula:</p><div class="Figure"><img alt="Chemical Structure" src="horizant-01.jpg"/></div><p>Gabapentin enacarbil is a white to off-white crystalline solid with a melting onset of approximately 64°C and a solubility of 0.5 mg/mL in water and 10.2 mg/mL in phosphate buffer (pH 6.3).</p><p>HORIZANT is administered orally. Each HORIZANT Extended-Release Tablet contains 300 mg or 600 mg of gabapentin enacarbil and the following inactive ingredients: colloidal silicon dioxide, dibasic calcium phosphate dihydrate, glyceryl behenate, magnesium stearate, sodium lauryl sulfate, and talc.</p></section>

Horizant

gabapentin enacarbil

gabapentin enacarbil 600 MG Extended Release Oral Tablet

gabapentin enacarbil 600 MG Extended Release Oral Tablet [Horizant]

gabapentin enacarbil 300 MG Extended Release Oral Tablet

gabapentin enacarbil 300 MG Extended Release Oral Tablet [Horizant]

gabapentin

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

Submit MSL Request 

Pharmacy List 

Coverage Authorization Request 

Coverage Authorization Appeals 

Letter of Medical Necessity: RLS

Enroll in Patient Savings Program 

About Horizant: Restless Leg Syndrome (RLS)

About Horizant: Postherpetic Neuralgia (PHN)

Patient Resources 

Doctor Discussion Guide: Restless Leg Syndrome (RLS)

FAQs: Restless Leg Syndrome (RLS)

FAQs: Postherpetic Neuralgia (PHN)

Instructions For Use: Postherpetic Neuralgia (PHN)

Instructions For Use: Restless Leg Syndrome (RLS)