What is the dosage of Iclusig?

Iclusig is available in 4 dosages, including 10 mg Tab, 15 mg Tab, 30 mg Tab and 45 mg Tab

What does Iclusig treat?

Iclusig treats Myeloid Leukemia

What is Iclusig made of?

Iclusig contains ponatinib which is a Kinase Inhibitor

How is Iclusig administered?

Iclusig is administered as a Oral Pill

What is Iclusig mechanism of action?

Iclusig mechanism of action is Protein Kinase Inhibitors

Dosage & Administration Efficacy safety testing Drug label Prior authorization Financial assistance

Patient education

Iclusig

(ponatinib)

ponatinib 10 MG Oral Tablet [Iclusig]ponatinib 15 MG Oral Tablet [Iclusig]

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BLACK BOX WARNING

Dosage & administration

* Recommended Dosage in CP-CML: Starting dose is 45 mg orally once daily with a reduction to 15 mg once daily upon achievement of ≤1% BCR-ABL1IS.
* Recommended Dosage in AP-CML, BP-CML, and Ph+ ALL: Starting dose is 45 mg orally once daily.
* Hepatic Impairment: Reduce the starting dose to 30 mg orally once daily.
* Iclusig may be taken with or without food.

eficacy, safety & testing

Iclusig clinical details

T315I Mutation

Mechanism of Action (MOA)

Efficacy: CML - OPTIC Trial

Efficacy: CML - PACE Trial

Safety Profile: CML - PACE Trial

Safety Profile: CML - OPTIC Trial

Dosing: CML

Dosing Considerations: CML

Efficacy: Ph+ ALL

Safety Profile: Ph+ ALL

Dosing: Ph+ ALL

drug label

Iclusig prescribing information

Have more Iclusig questions?

Submit MSL Request

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Need to report an Iclusig issue?

ONLINE FORMReport adverse event

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prior authorization

Iclusig Prior authorization resources

Complete Letter of Medical Necessity

NOT PROVIDED BY BRANDCoverage Authorization Request

Coverage Authorization Appeals

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Benefits investigation

Takeda Oncology Here2Assist Enrollment Form

Takeda Oncology Here2Assist Enrollment Form - Spanish

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Reimbursement help (FRM)

NOT PROVIDED BY BRANDReimbursement help (FRM) resources

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financial assistance

Iclusig Financial assistance options

Co-pay savings program

commercial only

Enroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

RapidStart Request Form - Bridge Program

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Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

under insured

no insurance

goverment insurance

65+

Takeda Oncology Patient Assistance Program

Takeda Oncology Patient Assistance Program - Spanish

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Iclusig Patient education

Getting started on Iclusig

NOT PROVIDED BY BRANDInstructions For Use: CML

NOT PROVIDED BY BRANDInstructions For Use: Ph+ ALL