What is the dosage of Imfinzi?

Imfinzi is available in 2 dosages, including 50 mg/ml Injection 10 ml and 50 mg/ml Injection 2.4 ml

What does Imfinzi treat?

Imfinzi treats Transitional Cell Carcinoma

What is Imfinzi made of?

Imfinzi contains durvalumab which is a Programmed Death Ligand-1 Blocker

How is Imfinzi administered?

Imfinzi is administered as a Injectable

What is Imfinzi mechanism of action?

Imfinzi mechanism of action is Programmed Death Ligand-1 Antagonists or Programmed Death Ligand-1-directed Antibody Interactions

Imfinzi

(durvalumab)

10 ML durvalumab 50 MG/ML Injection [Imfinzi]2.4 ML durvalumab 50 MG/ML Injection [Imfinzi]

NO BLACK BOX WARNING

Dosage & administration

* Administer IMFINZI as an intravenous infusion over 60 minutes after dilution.
* Stage III NSCLC:
* Weight ≥ 30 kg: 10 mg/kg every 2 weeks or 1,500 mg every 4 weeks
* Weight < 30 kg: 10 mg/kg every 2 weeks

* Metastatic NSCLC:
* Weight ≥ 30 kg: 1,500 mg every 3 weeks in combination with tremelimumab-actl 75 mg and platinum-based chemotherapy for 4 cycles, and then administer IMFINZI 1,500 mg every 4 weeks as a single agent with histology-based pemetrexed maintenance therapy every 4 weeks, and a fifth dose of tremelimumab-actl 75 mg in combination with IMFINZI dose 6 at week 16
* Weight < 30 kg: 20 mg/kg every 3 weeks in combination with tremelimumab-actl 1 mg/kg and platinum-based chemotherapy, and then administer IMFINZI 20 mg/kg every 4 weeks as a single agent with histology-based pemetrexed therapy every 4 weeks, and a fifth dose of tremelimumab-actl 1 mg/kg in combination with IMFINZI dose 6 at week 16

* ES-SCLC:
* Weight ≥ 30 kg: With etoposide and either carboplatin or cisplatin, administer IMFINZI 1,500 mg every 3 weeks in combination with chemotherapy, and then 1,500 mg every 4 weeks as a single agent
* Weight < 30 kg: With etoposide and either carboplatin or cisplatin, administer IMFINZI 20 mg/kg every 3 weeks in combination with chemotherapy, and then 10 mg/kg every 2 weeks as a single agent

* BTC:
* Weight ≥ 30 kg: administer IMFINZI 1,500 mg every 3 weeks in combination with chemotherapy, and then 1,500 mg every 4 weeks as a single agent
* Weight < 30 kg: administer IMFINZI 20 mg/kg every 3 weeks in combination with chemotherapy, and then 20 mg/kg every 4 weeks as a single agent

* uHCC:
* Weight ≥ 30 kg: IMFINZI 1,500 mg in combination with tremelimumab-actl 300 mg as a single dose at Cycle 1/Day 1, followed by IMFINZI as a single agent every 4 weeks
* Weight < 30 kg: IMFINZI 20 mg/kg in combination with tremelimumab-actl 4 mg/kg as a single dose at Cycle 1/Day 1, followed by IMFINZI as a single agent every 4 weeks

* See full Prescribing Information for preparation and administration instructions and dosage modifications for adverse reactions.

drug label

Imfinzi prescribing information

Have more Imfinzi questions?

Submit MSL Request

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Need to report an Imfinzi issue?

ONLINE FORMReport adverse event

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samples

Request Imfinzi samples

NOT PROVIDED BY BRANDView Online Sample Form

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prior authorization

Imfinzi Prior authorization resources

NOT PROVIDED BY BRANDComplete Letter of Medical Necessity

NOT PROVIDED BY BRANDCoverage Authorization Request

NOT PROVIDED BY BRANDCoverage Authorization Appeals

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Benefits investigation

Imfinzi Enrollment Form

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Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

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financial assistance

Imfinzi Financial assistance options

Co-pay savings program

commercial only

Imfinzi Enrollment Form

Enroll in Patient Savings Program - HCP Portal

Enroll in Patient Savings Program - Patient

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

Imfinzi Enrollment Form

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Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

under insured

no insurance

goverment insurance

65+

AZ & Me Prescription Savings Program - Patient Assistance Program

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Imfinzi Patient education

Getting started on Imfinzi

NOT PROVIDED BY BRANDInstructions For Use: Advanced or Metastatic Biliary Tract Cancer (BTC)

NOT PROVIDED BY BRANDInstructions For Use: Extensive-stage Small Cell Lung Cancer (ES-SCLC)

NOT PROVIDED BY BRANDInstructions For Use: Stage III Non-small Cell Lung Cancer (NSCLC)