Dosage & Administration Biomarker testing Drug label Prior authorization Pharmacy Financial assistance

Kadcyla

(trastuzumab)

ado-trastuzumab emtansine 100 MG Injection [KADCYLA]ado-trastuzumab emtansine 160 MG Injection [KADCYLA]

Dosage & administration

* Do not substitute KADCYLA for or with trastuzumab.
* HER2 Testing: Perform using FDA-approved tests by laboratories with demonstrated proficiency.
* For intravenous infusion only. Do not administer as an intravenous push or bolus. Do not use Dextrose (5%) solution.
* The recommended dose of KADCYLA is 3.6 mg/kg given as an intravenous infusion every 3 weeks (21-day cycle) until disease progression or unacceptable toxicity, or a total of 14 cycles for patients with EBC. Do not administer KADCYLA at doses greater than 3.6 mg/kg.
* Management of adverse reactions (infusion-related reactions, hepatotoxicity, left ventricular cardiac dysfunction, thrombocytopenia, pulmonary toxicity or peripheral neuropathy) may require temporary interruption, dose reduction, or treatment discontinuation of KADCYLA.

biomarker testing

Kadcyla clinical details

Genetic testing requirements were obtained from the NCCN guidelines for each cancer type.

drug label

Kadcyla prescribing information

Contact Medical Science Liaison Report Adverse Event

prior authorization

Kadcyla prior authorization resources

Most recent Kadcyla prior authorization forms

View By Payer

Verified: Nov 27, 2023Cigna - Kadcyla Prior Authorization Form

Verified: Nov 19, 2023Aetna - Medicare Part B Kadcyla Prior Authorization Form

Complete Letter of Medical Necessity

Coverage Authorization Appeals

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Benefits investigation

Prescriber Service & Patient Consent Form

Prescriber Service Form - Online Portal

Patient Consent Form - English

Patient Consent Form - Spanish

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pharmacy

Kadcyla preferred pharmacy

Pharmacy List

financial assistance

Kadcyla financial assistance options

Co-pay savings program

commercial only

Prescriber Service & Patient Consent Form

Prescriber Service Form - Online Portal

Patient Consent Form - English

Patient Consent Form - Spanish

Enroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Foundation programs

under insured

no insurance

goverment insurance

65+

Prescriber Service & Patient Consent Form

Prescriber Service Form - Online Portal

Patient Consent Form - English

Patient Consent Form - Spanish

Genentech Prescriber Foundation Form

Independent Financial Support Programs

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.