Liothyronine Sodium - Liothyronine Sodium tablet

• Thyroid hormones, including liothyronine sodium tablets, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss.
• In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction.
• Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects
  [see Adverse Reactions (6), Drug Interactions (7.7), and Overdosage (10)].

Liothyronine is an L-triiodothyronine (T3) indicated for:

• Hypothyroidism: As replacement in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism (1.1)
• Pituitary Thyrotropin (Thyroid-Stimulating Hormone, TSH) Suppression: As an adjunct to surgery and radioiodine therapy in the management of well-differentiated thyroid cancer (1.2)
• Thyroid Suppression Test: As a diagnostic agent in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy (1.3)

• Not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients. (1)
• Not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis. (1)

• Administer liothyronine sodium tablets orally once daily and individual dosage according to patient response and laboratory findings (2.1)
• See full prescribing information for recommended dosage for hypothyroidism (2.2) TSH suppression in well-differentiated thyroid cancer (2.3) and for thyroid suppression test (2.4)
• When switching a patient to liothyronine sodium tablets discontinue levothyroxine therapy and initiate liothyronine sodium tablets at a low dosage. Gradually increase the dose according to the patient’s response (2.5)
• Adequacy of therapy determined with periodic monitoring of TSH and T3 levels as well as clinical status (2.6)

Tablets (circular, white to off-white) available as follows:

• 5 mcg: debossed ‘589’ on one side and plain on other side

• 25 mcg: debossed ‘590’ on one side and breakline on other side

• 50 mcg: debossed ‘591’ on one side and breakline on other side

Pregnancy may require the use of higher doses of thyroid hormone (2.2, 8.1)