* Before initiating LUPKYNIS, establish an accurate baseline estimated glomerular filtration rate (eGFR) and check blood pressure (BP). * Use of LUPKYNIS is not recommended in patients with a baseline eGFR ≤45 mL/min/1.73 m2 unless the benefit exceeds the risk; these patients may be at increased risk for acute and/or chronic nephrotoxicity. ( 2.2, 5.3) * Do not initiate LUPKYNIS in patients with baseline BP >165/105 mmHg or with hypertensive emergency. ( 2.2, 5.4)
* Recommended starting dose: 23.7 mg orally, twice a day. ( 2.3) * Use LUPKYNIS in combination with mycophenolate mofetil (MMF) and corticosteroids. ( 2.3) * Modify the LUPKYNIS dose based on eGFR ( 2.3, 5.3): * Assess eGFR every two weeks for the first month, every four weeks through the first year, and quarterly thereafter. * If eGFR <60 mL/min/1.73 m2 and reduced from baseline by >20% and <30%, reduce the dose by 7.9 mg twice a day. Re-assess eGFR within two weeks; if eGFR is still reduced from baseline by >20%, reduce the dose again by 7.9 mg twice a day. * If eGFR <60 mL/min/1.73 m2 and reduced from baseline by ≥30%, discontinue LUPKYNIS. Re-assess eGFR within two weeks; consider re-initiating LUPKYNIS at a lower dose (7.9 mg twice a day) only if eGFR has returned to ≥80% of baseline. * For patients that had a decrease in dose due to eGFR, consider increasing the dose by 7.9 mg twice a day for each eGFR measurement that is ≥80% of baseline; do not exceed the starting dose.
* Monitor blood pressure every two weeks for the first month after initiating LUPKYNIS, and as clinically indicated thereafter. For patients with BP >165/105 mmHg or with hypertensive emergency, discontinue LUPKYNIS and initiate antihypertensive therapy. ( 2.3, 5.4) * If the patient has not experienced therapeutic benefit by 24 weeks, consider discontinuation of LUPKYNIS. ( 2.3)
Dosage Adjustments:
* Patients with severe renal impairment: the recommended dose is 15.8 mg twice daily. ( 2.4, 8.6) * Patients with mild and moderate hepatic impairment: the recommended dose is 15.8 mg twice daily. ( 2.4, 8.7)
Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)
Patient benefit
A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max
Patient eligibility
Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance
How to sign up
Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form
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people also ask
Lupkynis FAQs
How is the dosage of Lupkynis?Lupkynis is available in 1 dosages, including 7.9 mg Cap
What does Lupkynis treat?Lupkynis treats Lupus Nephritis
What is Lupkynis made of?Lupkynis contains voclosporin which is a Calcineurin Inhibitor Immunosuppressant
How Is Lupkynis Administered?Lupkynis is administered as a Oral Pill
What Are The Lupkynis Mechanism Of Action?Lupkynis mechanism of action is Calcineurin Inhibitors, Organic Anion Transporting Polypeptide 1B1 Inhibitors, Organic Anion Transporting Polypeptide 1B3 Inhibitors or P-Glycoprotein Inhibitors
FAQ Data Source
We receive information directly from the FDA and PrescriberPoint is updated as frequently as change are made available