Dosage & Administration Drug label Prior authorization Financial assistance

Mavyret

(glecaprevir / pibrentasvir)

Mavyret 50 MG / 20 MG per packet Oral PelletMavyret 100 MG / 40 MG Oral Tablet

Dosage & administration

* Testing Prior to the Initiation of Therapy: Test all patients for HBV infection by measuring HBsAg and anti-HBc.

* See recommended treatment duration for patients 3 years and older in tables below.

Treatment-Naïve Patients

	Treatment Duration
HCV Genotype	No Cirrhosis	Compensated Cirrhosis (Child-Pugh A)
1, 2, 3, 4, 5, or 6	8 weeks	8 weeks

Treatment-Experienced Patients

		Treatment Duration
HCV Genotype	Patients Previously Treated With a Regimen Containing:	No Cirrhosis	Compensated Cirrhosis (Child-Pugh A)
1	An NS5A inhibitor1 without prior treatment with an NS3/4A protease inhibitor (PI)	16 weeks	16 weeks
	An NS3/4A PI2 without prior treatment with an NS5A inhibitor	12 weeks	12 weeks
1, 2, 4, 5, or 6	PRS3	8 weeks	12 weeks
3	PRS3	16 weeks	16 weeks
* Treated with prior regimens containing ledipasvir and sofosbuvir or daclatasvir with (peg) interferon and ribavirin. * Treated with prior regimens containing simeprevir and sofosbuvir, or simeprevir, boceprevir, or telaprevir with (peg) interferon and ribavirin. * PRS=Prior treatment experience with regimens containing (peg) interferon, ribavirin, and/or sofosbuvir, but no prior treatment experience with an HCV NS3/4A PI or NS5A inhibitor.

* Recommended dosage in adults: Three tablets taken at the same time orally once daily (total daily dose: glecaprevir 300 mg and pibrentasvir 120 mg) with food.

* Recommended dosage in pediatric patients 3 years and older:
◦ Pediatric Patients 3 Years to Less than 12 Years Old: Dosing is based on weight. Refer to Table 3 of the full prescribing information for specific dosing guidelines based on body weight. Instructions for Use should be followed for preparation and administration of MAVYRET oral pellets.
◦ Pediatric Patients 12 Years of Age and Older, or Pediatric Patients Weighing at Least 45 kg: three tablets taken at the same time orally once daily (total daily dose: glecaprevir 300 mg and pibrentasvir 120 mg) with food.

* HCV/HIV-1 co-infection and patients with any degree of renal impairment: Follow the dosage recommendations in the tables above.

* Liver or Kidney Transplant Recipients: MAVYRET is recommended for 12 weeks in patients 3 years and older who are liver or kidney transplant recipients. A 16-week treatment duration is recommended in genotype 1-infected patients who are NS5A inhibitor-experienced without prior treatment with an NS3/4A PI or in genotype 3-infected patients who are PRS treatment-experienced.

drug label

Mavyret prescribing information

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prior authorization

Mavyret prior authorization resources

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financial assistance

Mavyret financial assistance options

Co-pay savings program

commercial only

PDFEnroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

patient education

Mavyret patient education

Getting started on Mavyret

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link