Dosage & Administration Biomarker testing Drug label Prior authorization Pharmacy Financial assistance

Nerlynx

(neratinib)

NERLYNX 40 MG Oral Tablet

NO BLACK BOX WARNING

Dosage & administration

* Premedication for diarrhea: When not using dose escalation, initiate loperamide with the first dose of NERLYNX and continue during the first 56 days of treatment. After day 56, use loperamide to maintain 1–2 bowel movements per day. ( 2.1, 2.2)
* Extended adjuvant treatment of early-stage breast cancer: 240 mg (6 tablets) given orally once daily, with food, continuously until disease recurrence for up to one year. ( 2.2)
* Advanced or metastatic breast cancer: 240 mg (6 tablets) given orally once daily with food on Days 1–21 of a 21-day cycle plus capecitabine (750 mg/m 2 given orally twice daily) on Days 1–14 of a 21-day cycle until disease progression or unacceptable toxicities. ( 2.2)
* Dose escalation: A two-week dose escalation for NERLYNX may also be initiated. ( 2.2)
* Dose interruptions and/or dose reductions are recommended based on individual safety and tolerability. ( 2.3)
* Hepatic impairment: Reduce starting dose to 80 mg in patients with severe hepatic impairment. ( 2.4)

biomarker testing

Nerlynx clinical details

Genetic testing requirements were obtained from the NCCN guidelines for each cancer type.

drug label

Nerlynx prescribing information

Contact Medical Science Liaison Report Adverse Event

prior authorization

Nerlynx prior authorization resources

Most recent Nerlynx prior authorization forms

View By Payer

Verified: Sep 28, 2023Cigna - Nerlynx Prior Authorization Form

PDFComplete Letter of Medical Necessity

PDFCoverage Authorization Appeals

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Benefits investigation

PDFNerlynx Enrollment Form

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pharmacy

Nerlynx preferred pharmacy

OTHERPharmacy List

financial assistance

Nerlynx financial assistance options

Co-pay savings program

commercial only

PDFNerlynx Enrollment Form

Enroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

PDFNerlynx Enrollment Form

OTHERNerlynx Quick Start Program

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Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

under insured

no insurance

goverment insurance

65+

PDFNerlynx Enrollment Form

OTHERPatient Assistance Program

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Nerlynx patient education

Getting started on Nerlynx

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link