Folic Acid Metabolism Inhibitors

Folate Analog Metabolic Inhibitor

Arthritis, Juvenile

Arthritis, Rheumatoid

Breast Neoplasms

Choriocarcinoma

Crohn Disease

Esophageal Neoplasms

Hydatidiform Mole

Leukemia

Lung Neoplasms

Mycosis Fungoides

Psoriasis

Osteosarcoma

Stomach Neoplasms

Testicular Neoplasms

<section class="Section" data-sectioncode="34089-3"><a name="ID_9e0ffc9b-f061-42fc-8846-19bd84b40bd2"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>Otrexup contains methotrexate, a folate analog metabolic inhibitor.Chemically, methotrexate is [N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-Lglutamic acid. The structural formula is:<div class="Figure"><a name="id-1012833735"></a><img alt="Structure" src="otrexup-01.jpg"/></div>C20H22N8O5   M.W.= 454.45Otrexup contains methotrexate in a sterile, preservative-free, unbuffered solution with a 27 gauge ½ inch needle for a single subcutaneous injection. Otrexup solution is yellow in color.Inactive ingredients include sodium chloride and water for injection, USP. The amounts of sodium chloride vary with the amount of methotrexate.<table><col width="36%"/><col width="8%"/><col width="8%"/><col width="8%"/><col width="8%"/><col width="8%"/><col width="8%"/><col width="8%"/><tbody class="Headless"><tr class="First"><td align="center" class="Botrule Lrule Rrule Toprule">Amount of methotrexate (mg) per 0.4 mL</td><td align="center" class="Botrule Lrule Rrule Toprule">10</td><td align="center" class="Botrule Lrule Rrule Toprule">12.5</td><td align="center" class="Botrule Lrule Rrule Toprule">15</td><td align="center" class="Botrule Lrule Rrule Toprule">17.5</td><td align="center" class="Botrule Lrule Rrule Toprule">20</td><td align="center" class="Botrule Lrule Rrule Toprule">22.5</td><td align="center" class="Botrule Lrule Rrule Toprule">25</td></tr><tr class="Last"><td align="center" class="Botrule Lrule Rrule Toprule">Amount of sodium chloride (mg) per 0.4 mL</td><td align="center" class="Botrule Lrule Rrule Toprule">1.96</td><td align="center" class="Botrule Lrule Rrule Toprule">2.04</td><td align="center" class="Botrule Lrule Rrule Toprule">1.60</td><td align="center" class="Botrule Lrule Rrule Toprule">1.48</td><td align="center" class="Botrule Lrule Rrule Toprule">1.28</td><td align="center" class="Botrule Lrule Rrule Toprule">0.92</td><td align="center" class="Botrule Lrule Rrule Toprule">0.56</td></tr></tbody></table>Hydrochloric acid and additional sodium hydroxide may have been added, if necessary, to adjust the pH to 8.0.</section>

Otrexup

0.4 ML methotrexate 25 MG/ML Auto-Injector

0.4 ML methotrexate 25 MG/ML Auto-Injector [Otrexup]

0.4 ML methotrexate 37.5 MG/ML Auto-Injector

0.4 ML methotrexate 37.5 MG/ML Auto-Injector [Otrexup]

0.4 ML methotrexate 50 MG/ML Auto-Injector

0.4 ML methotrexate 50 MG/ML Auto-Injector [Otrexup]

0.4 ML methotrexate 62.5 MG/ML Auto-Injector

0.4 ML methotrexate 62.5 MG/ML Auto-Injector [Otrexup]

0.4 ML methotrexate 18.8 MG/ML Auto-Injector

0.4 ML methotrexate 18.8 MG/ML Auto-Injector [Otrexup]

0.4 ML methotrexate 31.3 MG/ML Auto-Injector

0.4 ML methotrexate 31.3 MG/ML Auto-Injector [Otrexup]

0.4 ML methotrexate 43.8 MG/ML Auto-Injector

0.4 ML methotrexate 43.8 MG/ML Auto-Injector [Otrexup]

0.4 ML methotrexate 56.3 MG/ML Auto-Injector

0.4 ML methotrexate 56.3 MG/ML Auto-Injector [Otrexup]

methotrexate

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event

Prescribing Information

Medication Guide

Pharmacy List 

Online Order Form 

Coverage Authorization Request 

Coverage Authorization Appeals

Enroll in Patient Savings Program 

Formulary Information

About Otrexup

FAQs: Rheumatoid Arthritis , Plaque Psoriasis, Polyarticular Juvenile Idiopathic Arthritis (pJIA)

Instructions For Use: Rheumatoid Arthritis 

Instructions For Use: Plaque Psoriasis 

Instructions For Use: Polyarticular Juvenile Idiopathic Arthritis (pJIA)