RANK Ligand Blocking Activity

RANK Ligand Inhibitor

Osteoporosis, Postmenopausal

Osteoporotic Fractures

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-8"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Denosumab is a human IgG2 monoclonal antibody with affinity and specificity for human RANKL (receptor activator of nuclear factor kappa-B ligand).  Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.</p><p>Prolia (denosumab) injection is a sterile, preservative-free, clear, colorless to pale yellow solution for subcutaneous use.</p><p>Each 1 mL single-dose prefilled syringe of Prolia contains 60 mg denosumab (60 mg/mL solution), 4.7% sorbitol, 17 mM acetate, 0.01% polysorbate 20, Water for Injection (USP), and sodium hydroxide to a pH of 5.2.</p></section>

Prolia

denosumab

1 ML denosumab 60 MG/ML Prefilled Syringe

1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

Submit MSL Request 

Pharmacy List 

Billing & Coding Guide 

Buy & Bill Guide 

Reimbursement Information [Connect with a Red Pop-UP}

Coverage Authorization Request 

Coverage Authorization Appeals 

Prolia Insurance Verification & PA Form 

Enroll in Patient Savings Program 

Amgen Assist - HCP Office Portal 

Other HCP Resources 

About Prolia 

Side Effects 

Doctor Discussion Guide 

Instructions For Use: Osteoporosis in Men 

Instructions For Use: Postmenopausal Osteoporosis 

Instructions For Use: Glucocorticoid Induced Osteoporosis 

Instructions For Use: Prostate Cancer Treatment-Induced Bone Loss 

Instructions For Use: Breast Cancer Treatment-Induced Bone Loss 