PCSK9 Inhibitors

PCSK9 Inhibitor

Hypercholesterolemia

Atherosclerosis

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-8"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Evolocumab is a human monoclonal immunoglobulin G2 (IgG2) directed against human proprotein convertase subtilisin kexin type 9 (PCSK9). Evolocumab has an approximate molecular weight (MW) of 144 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.</p><p>REPATHA is a sterile, preservative-free, clear to opalescent, colorless to pale yellow solution for subcutaneous use. Each 1 mL single-dose prefilled syringe and single-dose prefilled SureClick<span class="Sup">®</span> autoinjector contains 140 mg evolocumab, acetate (1.2 mg), polysorbate 80 (0.1 mg), proline (25 mg) in Water for Injection, USP. Sodium hydroxide may be used to adjust to a pH of 5.0. Each single-dose Pushtronex<span class="Sup">®</span> system (on-body infusor with prefilled cartridge) delivers a 3.5 mL solution containing 420 mg evolocumab, acetate (4.2 mg), polysorbate 80 (0.35 mg), proline (89 mg) in Water for Injection, USP. Sodium hydroxide may be used to adjust to a pH of 5.0.</p></section>

REPATHA

evolocumab

1 ML evolocumab 140 MG/ML Auto-Injector

Repatha

1 ML evolocumab 140 MG/ML Auto-Injector [Repatha]

1 ML evolocumab 140 MG/ML Prefilled Syringe

1 ML evolocumab 140 MG/ML Prefilled Syringe [Repatha]

3.5 ML evolocumab 120 MG/ML Cartridge

3.5 ML evolocumab 120 MG/ML Cartridge [Repatha]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

Submit MSL Request 

Pharmacy List 

Formulary Information

Reimbursement Information 

Coding & Billing Guide 

Coverage Authorization Request (Through CoverMyMeds)

Coverage Authorization Appeals 

Letter of Medical Necessity 

PA Checklist: Atherosclerotic Cardiovascular Disease (ASCVD)

PA Checklist: Familial Hypercholesterolemia (FH)

Enroll in Patient Savings Program 

Other HCP Resources: Access

Other HCP Resources 

Other HCP Resources: Peer Perspectives 

Other HCP Resources: Expert Voices 

About Repatha 

Side Effects

Patient Stories 

RepathaReady Support Program 

FAQs: Risk Reduction in Cardiovascular Disease & Adjunct for LDL Reduction 

Intructions For Use: SureClick Autoinjector 

Instructions For Use: Prefilled Syringe 

Instructions For Use: Pushtronex System 

Patient Brochure 

Patient Brochure - Spanish 

Repatha Start Guide 

Repatha Start Guide - Spanish 

LDL Tracker 

Doctor Discussion Guide 