Dosage & Administration Efficacy safety testing Drug label Prior authorization Financial assistance

Rituxan hycela

(hyaluronidase / rituximab)

11.7 ML hyaluronidase, human recombinant 2000 UNT/ML / rituximab 120 MG/ML Injection [Rituxan Hycela]13.4 ML hyaluronidase, human recombinant 2000 UNT/ML / rituximab 120 MG/ML Injection [Rituxan Hycela]

BLACK BOX WARNING

Dosage & administration

* For subcutaneous use only
* All patients must receive at least one full dose of a rituximab product by intravenous infusion before receiving RITUXAN HYCELA by subcutaneous injection .
* FL/DLBCL: Administer 1,400 mg/23,400 Units (1,400 mg rituximab and 23,400 Units hyaluronidase human) subcutaneously according to recommended schedule .
* CLL: Administer 1,600 mg/26,800 Units (1,600 mg rituximab and 26,800 Units hyaluronidase human) subcutaneously according to recommended schedule .
* Premedicate with acetaminophen and antihistamine before each dose; in addition, consider premedication with glucocorticoids
* Administer specified volume into subcutaneous tissue of abdomen:
* 11.7 mL from 1,400 mg/23,400 Units vial over approximately 5 minutes.
* 13.4 mL from 1,600 mg/26,800 Units vial over approximately 7 minutes.
* Observe 15 minutes following administration

eficacy, safety & testing

Rituxan hycela clinical details

Mechanism of Action (MOA)

SABRINA Trial: 1L FL

MabEASE Trial: 1L Diffuse Large B-cell Lymphoma (DLBCL)

SAWYER Trial: 1L CLL

Dosing

Preparation

Administration

Product Information

PrefMab Patient Preference Trial: 1L DLBCL & FL

drug label

Rituxan hycela prescribing information

Have more Rituxan hycela questions?

Submit MSL Request

Learn More

Need to report a Rituxan hycela issue?

ONLINE FORMReport adverse event

Learn More

prior authorization

Rituxan hycela Prior authorization resources

Complete Letter of Medical Necessity

NOT PROVIDED BY BRANDCoverage Authorization Request

Coverage Authorization Appeals

Learn More

Benefits investigation

Combined Prescriber Service Form and Patient Consent Form

Prescriber Service Form - Online Portal

Patient Consent Form - English

Patient Consent Form - Spanish

Learn More

Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

Learn More

financial assistance

Rituxan hycela Financial assistance options

Co-pay savings program

commercial only

Combined Prescriber Service Form and Patient Consent Form

Prescriber Service Form - Online Portal

Patient Consent Form - English

Patient Consent Form - Spanish

Enroll in Patient Savings Program

Learn More

Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

Learn More

Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

under insured

no insurance

goverment insurance

65+

Combined Prescriber Service Form and Patient Consent Form

Prescriber Service Form - Online Portal

Patient Consent Form - English

Patient Consent Form - Spanish

Genentech Patient Assistance Program Application - Prescriber Form

Learn More

Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Rituxan hycela Patient education

Getting started on Rituxan hycela

NOT PROVIDED BY BRANDInstructions For Use: Follicular Lymphoma (FL)

NOT PROVIDED BY BRANDInstructions For Use: Previously Untreated Diffuse Large B- Cell Lymphoma ( DLBCL)

NOT PROVIDED BY BRANDInstructions For Use: Chronic Lymphocytic Leukemia (CLL)