What is the dosage of Rybrevant?

Rybrevant is available in 1 dosages, including 50 mg/ml Injection 7 ml

What does Rybrevant treat?

Rybrevant treats Carcinoma, Non-Small-Cell Lung

How is Rybrevant administered?

Rybrevant is administered as a Injectable

Rybrevant Prescribing & Dosing Schedule

Last Update: Oct, 22 2024

Rybrevant(amivantamab-vmjw)

Rybrevant 350 MG in 7 ML Injection

NO BOXED WARNING

Dosage & Administration

* The recommended dosage of RYBREVANT is based on baseline body weight and administered as an intravenous infusion after dilution. ( 2.3, 2.5, 2.6, 2.7)
* Administer premedications as recommended. ( 2.5)
* Administer via a peripheral line on Week 1 and Week 2 to reduce the risk of infusion-related reactions. ( 2.8)
* Administer RYBREVANT in combination with chemotherapy weekly for 4 weeks, with the initial dose as a split infusion in Week 1 on Day 1 and Day 2, then administer every 3 weeks starting at Week 7. ( 2.3)
* Administer RYBREVANT in combination with lazertinib or RYBREVANT as a single agent weekly for 5 weeks, with the initial dose as a split infusion in Week 1 on Day 1 and Day 2, then administer every 2 weeks starting at Week 7. ( 2.4)
* When administering RYBREVANT in combination with lazertinib, administer anticoagulant prophylaxis to prevent venous thromboembolic (VTE) events for the first four months of treatment. ( 2.4)
* Administer diluted RYBREVANT intravenously according to the infusion rates in Tables 8 and 9. ( 2.8)

Body Weight (at Baseline)	Dosage	Recommended Dose
RYBREVANT in Combination with Carboplatin and Pemetrexed
Less than 80 kg	Weeks 1–4	1,400 mg
Less than 80 kg	Week 7 onwards	1,750 mg
Greater than or equal to 80 kg	Weeks 1–4	1,750 mg
Greater than or equal to 80 kg	Week 7 onwards	2,100 mg
RYBREVANT in Combination with Lazertinib or RYBREVANT as a Single Agent
Less than 80 kg	Weeks 1–5 Week 7 onwards	1,050 mg
Greater than or equal to 80 kg	Weeks 1–5 Week 7 onwards	1,400 mg

Get Your Patient on Rybrevant

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Rybrevant Prescribing Information

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Rybrevant Prior Authorization Resources

Most recent state uniform prior authorization forms

Verified: Sep 24, 2024Arizona - Uniform Prior Authorization Form

Verified: Sep 24, 2024Colorado - Uniform Prior Authorization Form

Verified: Sep 24, 2024Hawaii - Uniform Prior Authorization Form

Verified: Sep 24, 2024Illinois - Uniform Prior Authorization Form

Verified: Sep 24, 2024Indiana - Uniform Prior Authorization Form

Verified: Sep 24, 2024Louisiana - Uniform Prior Authorization Form

Verified: Sep 24, 2024Minnesota - Uniform Prior Authorization Form

Verified: Sep 24, 2024New Hampshire - Uniform Prior Authorization Form

Verified: Sep 24, 2024New Mexico - Uniform Prior Authorization Form

Verified: Sep 24, 2024Oregon - Uniform Prior Authorization Form

Verified: Sep 24, 2024Texas - Uniform Prior Authorization Form

Verified: Oct 05, 2024Washington - Uniform Prior Authorization Form

Verified: Oct 05, 2024Wisconsin - Uniform Prior Authorization Form

Letter of Exception

Complete Letter of Medical Necessity

Benefits investigation

Rybrevant Benefits Investigation Form

Rybrevant Preferred Pharmacy

Pharmacy List

Rybrevant Financial Assistance Options

Copay savings program

Rybrevant Benefits Investigation Form

Enroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Foundation programs

J&J Patient Assistance Program - Eligibility Check

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and copays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

Rybrevant PubMed™ News

Rybrevant Patient Education

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