Type I interferon Receptor Antagonist

Type I interferon Receptor Antagonists

Lupus Vasculitis, Central Nervous System

<section class="Section" data-sectioncode="34089-3"><a name="ID_afb06fdc-a5ce-4ce2-8658-1a4bc3724190"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION </h1><p class="First">Anifrolumab-fnia is a type I interferon (IFN) receptor antagonist, immunoglobulin G1 kappa (IgG1κ) monoclonal antibody that is produced in mouse myeloma cells (NS0) by recombinant DNA technology. The molecular weight is approximately 148 kDa.</p><p>SAPHNELO (anifrolumab-fnia) injection is a sterile, preservative‑free, clear to opalescent, colorless to slightly yellow, solution for intravenous use. SAPHNELO contains anifrolumab-fnia at a concentration of 150 mg/mL in a single-dose vial.</p><p>Each vial contains 300 mg (150 mg/mL) of anifrolumab-fnia, L-histidine (3 mg), L-histidine hydrochloride monohydrate (6 mg), L-lysine hydrochloride (18 mg), polysorbate 80 (1 mg), trehalose dihydrate (98 mg), and Water for Injection, USP. The pH is 5.9.</p></section>

SAPHNELO

anifrolumab

anifrolumab-fnia

2 ML anifrolumab-fnia 150 MG/ML Injection

Saphnelo

2 ML anifrolumab-fnia 150 MG/ML Injection [Saphnelo]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Submit MSL Request 

Pharmacy List 

Reimbursement Information

How To Order Saphnelo

Access & Reimbursement Guide

Coverage Authorization Request

Coverage Authorization Appeals

Saphnelo Supports Access 360 Enrollment Form 

Saphnelo Supports Access 360 Enrollment Form - Spanish

Patient Authorization Form

Enroll in Patient Savings Program 

Denied Patient Savings Program Cover Sheet

Other HCP Resources: Videos

Other HCP Resources 

About Saphnelo 

Side Effects 

Receiving Saphnelo

FAQs: Systemic Lupus Erythematosus

Instruction For Use: Systemic Lupus Erythematosus

Patient Brochure 

Patient Brochure: Spanish

Doctor Discussion Guide 

Doctor Discussion Guide: Spanish

Copay Savings Brochure

Saphnelo Supports Brochure 

Saphnelo Supports Brochure: Spanish

Treatment Roadmap 

Treatment Roadmap: Spanish

Infusion Preparation Tips 

Infusion Preparation Tips: Spanish

Saphnelo Supports Program