What is the dosage of Signifor?

Signifor is available in 5 dosages, including 10 mg Injection, 20 mg Injection, 30 mg Injection, 40 mg Injection and 60 mg Injection

What does Signifor treat?

Signifor treats Cushing Syndrome

What is Signifor made of?

Signifor contains pasireotide which is a Somatostatin Analog

How is Signifor administered?

Signifor is administered as a Injectable

What is Signifor mechanism of action?

Signifor mechanism of action is Somatostatin Receptor Agonists

Dosage & Administration Drug label Samples Prior authorization Financial assistance

Patient education

Signifor

(pasireotide)

pasireotide 10 MG Injection [Signifor]pasireotide 20 MG Injection [Signifor]

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NO BLACK BOX WARNING

Dosage & administration

* Evaluate fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), liver enzyme tests, electrocardiogram (ECG), serum magnesium, and serum potassium prior to starting. ( 2.1)
* Optimize glucose control in patients with poorly controlled diabetes mellitus prior to starting. ( 2.1)
* Must be administered by a health care professional only by intramuscular injection in the right or left gluteus immediately after reconstitution. ( 2.2)
* Initial Dose:
* Acromegaly: The initial dose is 40 mg by intramuscular injection once every 4 weeks (every 28 days). ( 2.3)
* Cushing's Disease: The initial dose is 10 mg by intramuscular injection once every 4 weeks (every 28 days). ( 2.3)

* Adjust dose based on response and tolerability. ( 2.4)
* Patients with Hepatic Impairment:
* Child-Pugh B:
* Acromegaly: Recommended initial dose is 20 mg once every 4 weeks and maximum dose is 40 mg once every 4 weeks ( 2.5, 8.6)
* Cushing's Disease: Recommended initial dose is 10 mg once every 4 weeks and maximum dose is 20 mg once every 4 weeks ( 2.5, 8.6).

* Child-Pugh C: Avoid use in these patients ( 2.5, 8.6)

* Follow reconstitution and administration instructions. ( 2.6)

Signifor prescribing information

Have more Signifor questions?

Submit MSL Request

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Need to report a Signifor issue?

ONLINE FORMReport adverse event

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samples

Request Signifor samples

NOT PROVIDED BY BRANDView Online Sample Form

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prior authorization

Signifor Prior authorization resources

NOT PROVIDED BY BRANDComplete Letter of Medical Necessity

Coverage Authorization Request

Coverage Authorization Appeals

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Benefits investigation

Patient Support Start Form

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Reimbursement help (FRM)

NOT PROVIDED BY BRANDReimbursement help (FRM) resources

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financial assistance

Signifor Financial assistance options

Co-pay savings program

commercial only

Enroll in Patient Savings Program

Patient Support Start Form

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

Enroll in Bridge Program

Patient Support Start Form

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Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

under insured

no insurance

goverment insurance

65+

Patient Assistance Program

Patient Support Start Form

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement