Signifor

(pasireotide)

pasireotide 10 MG Injection [Signifor]pasireotide 20 MG Injection [Signifor]

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NO BLACK BOX WARNING

Dosage & administration

* Evaluate fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), liver enzyme tests, electrocardiogram (ECG), serum magnesium, and serum potassium prior to starting. ( 2.1)
* Optimize glucose control in patients with poorly controlled diabetes mellitus prior to starting. ( 2.1)
* Must be administered by a health care professional only by intramuscular injection in the right or left gluteus immediately after reconstitution. ( 2.2)
* Initial Dose:
* Acromegaly: The initial dose is 40 mg by intramuscular injection once every 4 weeks (every 28 days). ( 2.3)
* Cushing's Disease: The initial dose is 10 mg by intramuscular injection once every 4 weeks (every 28 days). ( 2.3)

* Adjust dose based on response and tolerability. ( 2.4)
* Patients with Hepatic Impairment:
* Child-Pugh B:
* Acromegaly: Recommended initial dose is 20 mg once every 4 weeks and maximum dose is 40 mg once every 4 weeks ( 2.5, 8.6)
* Cushing's Disease: Recommended initial dose is 10 mg once every 4 weeks and maximum dose is 20 mg once every 4 weeks ( 2.5, 8.6).

* Child-Pugh C: Avoid use in these patients ( 2.5, 8.6)

* Follow reconstitution and administration instructions. ( 2.6)

drug label

Signifor prescribing information

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prior authorization

Signifor prior authorization resources

Most recent Signifor prior authorization forms

View By Payer

Updated: Jun 04, 2023Blue Cross Blue Shield of Michigan - FEP Signifor LAR Prior Authorization Form (Medical Benefit)

Updated: May 31, 2023Cigna - Signifor LAR Prior Authorization Form

Updated: May 29, 2023Blue Cross Blue Shield of Michigan - Signifor LAR Prior Authorization Form (Medical Benefit)

Updated: May 24, 2023Aetna - Signifor LAR Prior Authorization Form

Updated: May 24, 2023Aetna - Medicare Part B Signifor LAR Prior Authorization Form

Coverage Authorization Request

Coverage Authorization Appeals

PDFR.A.R.E. Patient Support Start Form

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Benefits investigation

PDFR.A.R.E. Patient Support Start Form

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Reimbursement help (FRM)

OTHERReceive Assistance from an FRM Regarding Reimbursement Information

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pharmacy

Signifor preferred pharmacy

PDFPharmacy List

financial assistance

Signifor financial assistance options

Co-pay savings program

commercial only

PDFR.A.R.E. Patient Support Start Form

OTHEREnroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Foundation programs

under insured

no insurance

goverment insurance

65+

PDFR.A.R.E. Patient Support Start Form

OTHERPatient Assistance Program

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Signifor patient education

Getting started on Signifor

BRAND PAGEInstructions For Use: Acromegaly

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGEInstructions For Use: Cushing's Disease

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link

Patient toolkit

BRAND PAGEAbout Signifor LAR: Cushing's Disease

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHERPatient Resources: Cushing's Disease

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGEAbout Signifor LAR: Acromegaly

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHERPatient Resources: Acromegaly

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDFPatient Brochure: Cushing's Disease

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDFSymptom Diary: Cushing's Disease

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDFDisease Overview Brochure: Cushing's Disease

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDFDisease Overview Brochure: Acromegaly

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDFSymptom Diary: Acromegaly

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Learn More

Other resources

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Signifor FAQs

How is the dosage of Signifor?Signifor is available in 5 dosages, including 10 mg Injection, 20 mg Injection, 30 mg Injection, 40 mg Injection and 60 mg Injection

What does Signifor treat?Signifor treats Cushing Syndrome

What is Signifor made of?Signifor contains pasireotide which is a Somatostatin Analog

How Is Signifor Administered?Signifor is administered as a Injectable

What Are The Signifor Mechanism Of Action?Signifor mechanism of action is Somatostatin Receptor Agonists

FAQ Data Source

Signifor

Dosage & administration

drug label

Signifor prescribing information

prior authorization

Signifor prior authorization resources

Most recent Signifor prior authorization forms

Benefits investigation

Reimbursement help (FRM)

pharmacy

Signifor preferred pharmacy

financial assistance

Signifor financial assistance options

Co-pay savings program

Foundation programs

patient education

Signifor patient education

Getting started on Signifor

Patient toolkit

Other resources

people also ask

Signifor FAQs