Texacort

Texacort Topical Solution 2.5% is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroids-responsive dermatoses.

Topical corticosteroids are generally applied to the affected area as a thin film for three or four times daily depending on the severity of the condition.

Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions.

If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria.

Topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Texacort Topical Solution contains hydrocortisone as the active corticosteroid, having the chemical formula of Pregn-4-ene-3, 20-dione, 11,17,21-trihydroxy-, (11 β)-. The molecular weight is 362.47. Its empirical formula is C
₂₁H
₃₀O
₅and the structural formula is:

Each milliliter contains 25 mg of hydrocortisone (2.5% W/V) in a specially formulated vehicle containing alcohol (48.8% W/W), purified water, polysorbate 20 and isoceteth-20.

Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions.

The mechanisms of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.