Dosage & Administration Drug label People also ask

Elexacaftor / ivacaftor / tezacaftor

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Dosage & administration

Recommended Dosage for Adult and Pediatric Patients aged 6 Years and Older
Age	Morning Dose	Evening Dose
6 to less than 12 years weighing less than 30 kgs	Two tablets, each containing elexacaftor 50 mg/tezacaftor 25 mg/ivacaftor 37.5 mg	One tablet of ivacaftor 75 mg
6 to less than 12 years weighing 30 kgs or more	Two tablets, each containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg	One tablet of ivacaftor 150 mg
12 years and older	Two tablets, each containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg	One tablet of ivacaftor 150 mg

* TRIKAFTA should be taken with fat-containing food.
* Should not be used in patients with severe hepatic impairment. Use not recommended in patients with moderate hepatic impairment unless the benefit exceeds the risk. Reduce dose if used in patients with moderate hepatic impairment. Liver function tests should be closely monitored.
* See full prescribing information for dosage modifications due to drug interactions with TRIKAFTA.

drug label

Elexacaftor / ivacaftor / tezacaftor prescribing information

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financial assistance

Elexacaftor / ivacaftor / tezacaftor financial assistance options

Co-pay savings program

commercial only

Enroll in Patient Savings Program

Vertex GPS Patient Enrollment Form

Vertex GPS Patient Enrollment Form - Spanish

Vertex GPS Patient Enrollment Form - Online

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Elexacaftor / ivacaftor / tezacaftor FAQs

How is the dosage of Elexacaftor / ivacaftor / tezacaftor? is available in 2 dosages, including mixed Pack and mixed Pack

What does Elexacaftor / ivacaftor / tezacaftor treat? treats Cystic Fibrosis

What is Elexacaftor / ivacaftor / tezacaftor made of? contains elexacaftor / ivacaftor / tezacaftor which is a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator

How Is Elexacaftor / ivacaftor / tezacaftor Administered? is administered as a Pack

What Are The Elexacaftor / ivacaftor / tezacaftor Mechanism Of Action? mechanism of action is Chloride Channel Activation Potentiators, Cytochrome P450 2C9 Inhibitors, Cytochrome P450 3A Inhibitors, Cytochrome P450 3A4 Inhibitors or P-Glycoprotein Inhibitors

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