Dosage & Administration

Prior to initiating TRIKAFTA obtain liver function tests (ALT, AST, alkaline phosphatase, and bilirubin) in all patients. Monitor liver function tests every month during the first 6 months of treatment, then every 3 months during the next 12 months, then at least annually thereafter. )AgeWeightMorning DoseEvening Dose2 to less than 6 years Less than 14 kgOne packet containing elexacaftor 80 mg/tezacaftor 40 mg/ivacaftor 60 mg oral granulesOne packet containing ivacaftor 59.5 mg oral granules14 kg or moreOne packet containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg oral granulesOne packet containing ivacaftor 75 mg oral granules6 to less than 12 yearsLess than 30 kgTwo tablets, each containing elexacaftor 50 mg/tezacaftor 25 mg/ivacaftor 37.5 mgOne tablet of ivacaftor 75 mg30 kg or moreTwo tablets, each containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mgOne tablet of ivacaftor 150 mg12 years and older-Two tablets, each containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mgOne tablet of ivacaftor 150 mg

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