Triple Negative Breast Neoplasms

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Sacituzumab govitecan-hziy is a Trop-2 directed antibody and topoisomerase inhibitor conjugate, composed of the following three components:</p><ul class="Disc"><li>the humanized monoclonal antibody, hRS7 IgG1κ (also called sacituzumab), which binds to Trop-2 (the trophoblast cell-surface antigen-2);</li><li>the drug SN-38, a topoisomerase inhibitor;</li><li>a hydrolysable linker (called CL2A), which links the humanized monoclonal antibody to SN-38.</li></ul><p>The recombinant monoclonal antibody is produced by mammalian (murine myeloma) cells, while the small molecule components SN-38 and CL2A are produced by chemical synthesis. Sacituzumab govitecan-hziy contains on average 7 to 8 molecules of SN-38 per antibody molecule. Sacituzumab govitecan-hziy has a molecular weight of approximately 160 kilodaltons. Sacituzumab govitecan-hziy has the following chemical structure.</p><div class="Figure"><img alt="Chemical Structure" src="trodelvy-01.jpg"/></div><p>TRODELVY (sacituzumab govitecan-hziy) for injection is a sterile, preservative-free, off-white to yellowish lyophilized powder for intravenous use in a 50 mL clear glass single-dose vial, with a rubber stopper and crimp-sealed with an aluminum flip-off cap.</p><p>Each single-dose vial of TRODELVY delivers 180 mg sacituzumab govitecan-hziy, 71.7 mg 2-(N-morpholino) ethane sulfonic acid (MES), 1.8 mg polysorbate 80 and 153.99 mg trehalose. Reconstitution with 20 mL of 0.9% Sodium Chloride Injection, USP, results in a concentration of 10 mg/mL with a pH of 6.5.</p></section>

TRODELVY

sacituzumab

sacituzumab govitecan-hziy

sacituzumab govitecan-hziy 180 MG Injection

Trodelvy

sacituzumab govitecan-hziy 180 MG Injection [Trodelvy]

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About Trodelvy: Metastatic Triple Negative Breast Cancer

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