Nucleic Acid Synthesis Inhibitors

Nucleoside Metabolic Inhibitor

Topoisomerase Inhibitors

Anthracycline Topoisomerase Inhibitor

Leukemia

Lymphoma

Meningeal Neoplasms

Leukemia, Myeloid, Acute

Precursor Cell Lymphoblastic Leukemia-Lymphoma

<section class="Section" data-sectioncode="34089-3"><a name="i4i_description_id_a2eb0438-558c-41b3-8044-a8f49cf855c1"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">VYXEOS (daunorubicin and cytarabine) liposome for injection is a combination of daunorubicin and cytarabine in a 1:5 molar ratio encapsulated in liposomes for intravenous administration. The liposome membrane is composed of distearoylphosphatidylcholine (DSPC), distearoylphosphatidylglycerol (DSPG), and cholesterol in a 7:2:1 molar ratio.</p><p>Daunorubicin is an anthracycline topoisomerase inhibitor. The chemical name for daunorubicin is (1S,3S)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside; its molecular weight is 527.52. Daunorubicin has the following structural formula:</p><div class="Figure"><a name="id189113651"></a><img alt="daunorubicin" src="image-02.jpg"/></div><p>Cytarabine is a nucleoside metabolic inhibitor. The chemical name of cytarabine is 4-amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone; its molecular weight is 243.22. Cytarabine has the following structural formula:</p><div class="Figure"><a name="id-696008170"></a><img alt="cytarabine" src="image-03.jpg"/></div><p>VYXEOS liposome for injection is supplied as a sterile, preservative-free, purple, lyophilized cake, in a single-dose vial. Each vial contains 44 mg daunorubicin and 100 mg cytarabine, and the following inactive ingredients: distearoylphosphatidylcholine 454 mg, distearoylphosphatidylglycerol 132 mg, cholesterol HP 32 mg, copper gluconate 100 mg, triethanolamine 4 mg, and sucrose 2054 mg.</p></section>

VYXEOS

cytarabine liposome 100 MG / daunorubicin liposomal 44 MG Injection

Vyxeos

cytarabine liposome 100 MG / daunorubicin liposomal 44 MG Injection [Vyxeos]

cytarabine / daunorubicin

daunorubicin liposomal

cytarabine

daunorubicin

cytarabine liposome

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information

Submit MSL Request 

Pharmacy List 

Reimbursement Information

Coding Guide

How To Order Vyxeos

JazzCares Enrollment Form

JazzCares Enrollment Form - Online

Coverage Authorization Request 

Coverage Authorization Appeals 

Enroll in Patient Savings Program 

Patient Assistance Program 

Other HCP Resources

Patient Brochure

About Vyxeos 

Receiving Vyxeos

What To Expect With Vyxeos

Patient Stories 

FAQs: AML

Patient Resources 

Doctor Discussion Guide

Instructions For Use: AML