What is the dosage of Xgeva?

Xgeva is available in 1 dosages, including 70 mg/ml Injection 1.7 ml

What does Xgeva treat?

Xgeva treats Postmenopausal Osteoporosis and Osteoporotic Fractures

What is Xgeva made of?

Xgeva contains denosumab which is a RANK Ligand Inhibitor

How is Xgeva administered?

Xgeva is administered as a Injectable

What is Xgeva mechanism of action?

Xgeva mechanism of action is RANK Ligand Blocking Activity

Dosage & Administration Drug label Samples Prior authorization Financial assistance

Patient education

Xgeva

(denosumab)

1.7 ML denosumab 70 MG/ML Injection [Xgeva]

NO BLACK BOX WARNING

Dosage & administration

* Xgeva is intended for subcutaneous route only and should not be administered intravenously, intramuscularly, or intradermally.

* Multiple Myeloma and Bone Metastasis from Solid Tumors: Administer 120 mg every 4 weeks as a subcutaneous injection in the upper arm, upper thigh, or abdomen.

* Giant Cell Tumor of Bone: Administer 120 mg every 4 weeks with additional 120 mg doses on Days 8 and 15 of the first month of therapy. Administer subcutaneously in the upper arm, upper thigh, or abdomen.

* Administer calcium and vitamin D as necessary to treat or prevent hypocalcemia.

* Hypercalcemia of Malignancy: Administer 120 mg every 4 weeks with additional 120 mg doses on Days 8 and 15 of the first month of therapy. Administer subcutaneously in the upper arm, upper thigh, or abdomen.

drug label

Xgeva prescribing information

Have more Xgeva questions?

Submit MSL Request

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Need to report a Xgeva issue?

ONLINE FORMReport adverse event

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samples

Request Xgeva samples

NOT PROVIDED BY BRANDView Online Sample Form

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prior authorization

Xgeva Prior authorization resources

Complete Letter of Medical Necessity

NOT PROVIDED BY BRANDCoverage Authorization Request

NOT PROVIDED BY BRANDComplete Coverage Authorization appeals

Coverage Auhtorization Appeals

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Benefits investigation

Benefit Verification

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Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

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financial assistance

Xgeva Financial assistance options

Co-pay savings program

commercial only

Enroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

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Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

under insured

no insurance

goverment insurance

65+

Amgen Safety Net Foundation Patient Assistance Program

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Xgeva Patient education

Getting started on Xgeva

NOT PROVIDED BY BRANDInstructions For Use: Prevention of Skeletal-Related Events in Patients With Multiple Myeloma and Bone Metastases From Solid Tumors