Xyrem Prescribing & Dosing Schedule

Dosage & Administration Drug label Prior authorization Pharmacy Financial assistance Patient education People also ask

Xyrem (sodium oxybate)

XYREM 0.5 GM in 1 mL Oral Solution

Dosage & Administration

Dosage for Adult Patients

* Initiate dosage at 4.5 g per night orally, divided into two doses .
* Titrate to effect in increments of 1.5 g per night at weekly intervals (0.75 g at bedtime and 0.75 g taken 2.5 to 4 hours later) .
* Recommended dosage range: 6 g to 9 g per night orally .

Total Nightly Dose	Take at Bedtime	Take 2.5 to 4 Hours Later
4.5 g per night	2.25 g	2.25 g
6 g per night	3 g	3 g
7.5 g per night	3.75 g	3.75 g
9 g per night	4.5 g	4.5 g

Dosage for Pediatric Patients (7 years of Age and Older)

* The recommended starting dosage, titration regimen, and maximum total nightly dosage are based on body weight (2.2).

Important Administration Information

* Prepare both doses prior to bedtime; dilute each dose with approximately ¼ cup of water in pharmacy-provided containers .
* Allow 2 hours after eating before dosing .
* Take each dose while in bed and lie down after dosing .

Patients with Hepatic Impairment

Recommended starting dosage is one-half of the original dosage per night administered orally, divided into two doses .

drug label

Xyrem Prescribing Information

Contact Medical Science Liaison

Report Adverse Event

prior authorization

Xyrem Prior Authorization Resources

Most recent state uniform prior authorization forms

Verified: Jun 26, 2024Arizona - Uniform Prior Authorization Form

Verified: Jun 26, 2024Colorado - Uniform Prior Authorization Form

Verified: Jun 26, 2024Hawaii - Uniform Prior Authorization Form

Verified: Jul 26, 2024Illinois - Uniform Prior Authorization Form

Verified: Jun 26, 2024Indiana - Uniform Prior Authorization Form

Verified: Jun 26, 2024Louisiana - Uniform Prior Authorization Form

Verified: Jun 26, 2024Minnesota - Uniform Prior Authorization Form

Verified: Jun 26, 2024New Hampshire - Uniform Prior Authorization Form

Verified: Jun 26, 2024New Mexico - Uniform Prior Authorization Form

Verified: Jun 26, 2024Oregon - Uniform Prior Authorization Form

Verified: Jun 26, 2024Texas - Uniform Prior Authorization Form

Verified: Jul 07, 2024Washington - Uniform Prior Authorization Form

Verified: Jul 07, 2024Wisconsin - Uniform Prior Authorization Form

Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

pharmacy

Xyrem Preferred Pharmacy

Pharmacy List

financial assistance

Xyrem Financial Assistance Options

Copay savings program

Enroll in Patient Savings Program

Learn More

Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Foundation programs

JazzCares Patient Assistance Program

Learn More

Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and copays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Xyrem Patient Education

Getting started on Xyrem

Instructions For Use: Narcolepsy (Adults)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Instructions For Use: Narcolepsy (Pediatrics)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link

Patient toolkit

About Xyrem: Adults

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

About Xyrem: Pediatrics

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Getting Xyrem

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Doctor Discussion Guide

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Xyrem FAQs

How is the dosage of Xyrem ?Xyrem is available in 1 dosages, including 500 mg/ml Sol

What does Xyrem treat?Xyrem treats Cataplexy

What is Xyrem made of?Xyrem contains oxybate which is a Central Nervous System Depressant

How Is Xyrem Administered?Xyrem is administered as a Oral Liquid

FAQ Data Source

Dosage & Administration

Dosage & Administration

drug label

Xyrem Prescribing Information

prior authorization

Xyrem Prior Authorization Resources

Most recent state uniform prior authorization forms

Reimbursement help (FRM)

pharmacy

Xyrem Preferred Pharmacy

financial assistance

Xyrem Financial Assistance Options

Copay savings program

Foundation programs

patient education

Xyrem Patient Education

Getting started on Xyrem

Patient toolkit

people also ask

Xyrem FAQs