What is the dosage of Xyrem?

Xyrem is available in 1 dosages, including 500 mg/ml Sol

What is Xyrem made of?

Xyrem contains oxybate which is a Central Nervous System Depressant

How is Xyrem administered?

Xyrem is administered as a Oral Liquid

Dosage & Administration Drug label Samples Prior authorization Financial assistance

Patient education

Xyrem

(oxybate)

sodium oxybate 500 MG/ML Oral Solution [Xyrem]

BLACK BOX WARNING

Dosage & administration

Dosage for Adult Patients

* Initiate dosage at 4.5 g per night orally, divided into two doses .
* Titrate to effect in increments of 1.5 g per night at weekly intervals (0.75 g at bedtime and 0.75 g taken 2.5 to 4 hours later) .
* Recommended dosage range: 6 g to 9 g per night orally .

Total Nightly Dose	Take at Bedtime	Take 2.5 to 4 Hours Later
4.5 g per night	2.25 g	2.25 g
6 g per night	3 g	3 g
7.5 g per night	3.75 g	3.75 g
9 g per night	4.5 g	4.5 g

Dosage for Pediatric Patients (7 years of Age and Older)

* The recommended starting dosage, titration regimen, and maximum total nightly dosage are based on body weight (2.2).

Important Administration Information

* Prepare both doses prior to bedtime; dilute each dose with approximately ¼ cup of water in pharmacy-provided containers .
* Allow 2 hours after eating before dosing .
* Take each dose while in bed and lie down after dosing .

Patients with Hepatic Impairment

Recommended starting dosage is one-half of the original dosage per night administered orally, divided into two doses .

Xyrem prescribing information

Have more Xyrem questions?

Submit MSL Request

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Need to report a Xyrem issue?

ONLINE FORMReport adverse event

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samples

Request Xyrem samples

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prior authorization

Xyrem Prior authorization resources

Complete Letter of Medical Necessity

NOT PROVIDED BY BRANDCoverage Authorization Request

NOT PROVIDED BY BRANDCoverage Authorization Appeals

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Benefits investigation

Patient Authorization Form - Online

Patient Authorization Form - English (Print Form)

Patient Authorization Form - Spanish (Print Form)

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Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

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financial assistance

Xyrem Financial assistance options

Co-pay savings program

commercial only

Patient Authorization Form - Online

Patient Authorization Form - English (Print Form)

Patient Authorization Form - Spanish (Print Form)

Enroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

Patient Authorization Form - Online

Patient Authorization Form - English (Print Form)

Patient Authorization Form - Spanish (Print Form)

Enroll in Bridge Program

Quick Start Voucher - 1 month supply

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Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

under insured

no insurance

goverment insurance

65+

JazzCares Patient Assistance Application Program

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Xyrem Patient education

Getting started on Xyrem

Instructions For Use - Narcolepsy Adults

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Instructions For Use - Narcolepsy Children & Adolescents

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Patient toolkit

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Can't find what you're looking for?

Our trained staff can help you:

Please note:

Access to a Field Reimbursement Manager (FRM) or Medical Science Liaison (MSL) varies by brand and may require talking with your rep first.
Samples are provided at the discretion of the brand.
We are unable to collect Protected Health Information (PHI), fill out forms, or submit them on your behalf.

Xyrem

Dosage & administration

Most viewed Xyrem resources

drug label

Xyrem prescribing information

Have more Xyrem questions?

Need to report a Xyrem issue?

samples

Request Xyrem samples

Is my patient elegible for Xyrem samples?

How do I find out who my Xyrem rep is?

prior authorization

Xyrem Prior authorization resources

Benefits investigation

Reimbursement help (FRM)

financial assistance

Xyrem Financial assistance options

Co-pay savings program

Overview

Patient benefit

Patient eligibility

How to sign up

Bridge program

Overview

Patient benefit

Patient eligibility

How to sign up

Foundation programs

Overview

Patient benefit

Patient eligibility

How to sign up

patient education

Xyrem Patient education

Getting started on Xyrem

Patient toolkit

Can't find what you're looking for?