What is the dosage of Xywav?

Xywav is available in 1 dosages, including 234-96-130-40 mg/ml Sol

Xywav Prescribing & Dosing Schedule

Q: What is Xywav made of?

Xywav contains calcium oxybate / magnesium oxybate / potassium oxybate / sodium oxybate which is a Central Nervous System Depressant

Q: How is Xywav administered?

Xywav is administered as a Oral Liquid

Last Update: Oct, 13 2024

Xywav (calcium oxybate)

xywav 0.5 GM in 1 mL Oral Solution

BOXED WARNING

Dosage & Administration

See Full Prescribing Information for complete dosing instructions .

Dosage for Adult Patients with Narcolepsy

* Initiate dosage at 4.5 g per night orally, divided into two doses .
* Titrate to effect in increments of up to 1.5 g per night per week .
* Recommended dosage range: 6 g to 9 g per night orally, divided into two doses .
* Doses may be divided equally or unequally and the first dose taken at bedtime and the second dose taken 2.5 to 4 hours later .

Dosage for Pediatric Patients with Narcolepsy (7 Years of Age and Older)

* The recommended starting dosage, titration regimen, and maximum total nightly dosage are based on body weight (2.2).

Dosage for Adult Patients with Idiopathic Hypersomnia

* XYWAV can be administered as a twice or once nightly regimen in adults .
* Twice nightly: Initiate dosage at 4.5 g or less per night orally, divided into two doses. Titrate to effect in increments of up to 1.5 g per night per week, up to 9 g total nightly dose .
* Once nightly: Initiate dosage at 3 g or less per night orally, as one dose. Titrate to effect in increments of up to 1.5 g per night per week, up to 6 g total nightly dose .

Important Administration Information

* Administer XYWAV at least 2 hours after eating .
* Prepare XYWAV prior to bedtime; dilute with approximately ¼ cup of water in pharmacy-provided containers .
* Take XYWAV while in bed and lie down after dosing .

For Patients Transitioning from Xyrem to XYWAV: Initiate at the same dose and regimen as Xyrem (gram for gram). Titrate as needed based on efficacy and tolerability .

Patients with Hepatic Impairment

Recommended starting dosage is one-half of the original dosage per night administered orally, divided into two doses .

Get Your Patient on Xywav

See your patient's specific prior authorization requirements including coverage restrictions and step therapies

Or select your Insurance from the list below:

Xywav Prescribing Information

Contact Medical Science Liaison

Report Adverse Event

Xywav Prior Authorization Resources

Most recent state uniform prior authorization forms

Verified: Sep 24, 2024Arizona - Uniform Prior Authorization Form

Verified: Sep 24, 2024Colorado - Uniform Prior Authorization Form

Verified: Sep 24, 2024Hawaii - Uniform Prior Authorization Form

Verified: Sep 24, 2024Illinois - Uniform Prior Authorization Form

Verified: Sep 24, 2024Indiana - Uniform Prior Authorization Form

Verified: Sep 24, 2024Louisiana - Uniform Prior Authorization Form

Verified: Sep 24, 2024Minnesota - Uniform Prior Authorization Form

Verified: Sep 24, 2024New Hampshire - Uniform Prior Authorization Form

Verified: Sep 24, 2024New Mexico - Uniform Prior Authorization Form

Verified: Sep 24, 2024Oregon - Uniform Prior Authorization Form

Verified: Sep 24, 2024Texas - Uniform Prior Authorization Form

Verified: Oct 05, 2024Washington - Uniform Prior Authorization Form

Verified: Oct 05, 2024Wisconsin - Uniform Prior Authorization Form

Formulary Exception Process Guide

Guide to Completing Prior Authorization: Idiopathic Hypersomnia

Guide to Completing Prior Authorization: Narcolepsy

Letter of Medical Necessity: Idiopathic Hypersomnia

Letter of Medical Necessity: Narcolepsy

Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

Xywav Preferred Pharmacy

Pharmacy List

Xywav Financial Assistance Options

Copay savings program

Enroll in Patient Savings Program

Learn More

Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

Enroll in Bridge Program

Quick Start Voucher Program

Learn More

Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

JazzCares Patient Assistance Program

Learn More

Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and copays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.