Phosphodiesterase 4 Inhibitors

Phosphodiesterase 4 Inhibitor

Pulmonary Disease, Chronic Obstructive

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-8"></a><h1>11 DESCRIPTION</h1>ZORYVE (roflumilast) cream is a white to off-white cream for topical use. The active ingredient, roflumilast, is a phosphodiesterase 4 (PDE4) inhibitor.Roflumilast is described chemically as 3-cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide. The empirical formula is C17H14Cl2F2N2O3, and the molecular weight is 403.21.The structural formula is represented below:<img alt="Chemical Structure" src="roflumilast-01.jpg"/>Roflumilast is practically insoluble in water and hexane, sparingly soluble in ethanol, and freely soluble in acetone.Each gram of cream, 0.15% or 0.3%, contains 1.5 mg or 3 mg of roflumilast, respectively, in a cream base containing ceteareth-10 phosphate, cetearyl phosphate, cetostearyl alcohol, diethylene glycol monoethyl ether, hexylene glycol, isopropyl palmitate, methylparaben, propylparaben, purified water, sodium hydroxide, and white petrolatum. Hydrochloric acid may have been added to adjust pH.</section>

ZORYVE

roflumilast

roflumilast 3 MG/ML Topical Cream

Zoryve

roflumilast 3 MG/ML Topical Cream [Zoryve]

roflumilast 1.5 MG/ML Topical Cream

roflumilast 1.5 MG/ML Topical Cream [Zoryve]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

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Ubrelvy

Nurtec ODT

Vyepti

Aimovig

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Verzenio

Ibrance

Kisqali

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Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

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Orencia

COVID-19 Treatment

Alopecia Areata

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Zeposia

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Entyvio

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