Partial Opioid Agonists

Partial Opioid Agonist

Opioid Antagonists

Opioid Antagonist

Heroin Dependence

Opioid-Related Disorders

Pain

Respiration Disorders

Shock, Septic

<section class="Section" data-sectioncode="34089-3"><a name="section-11"></a><h1>11 DESCRIPTION </h1>      ZUBSOLV (buprenorphine and naloxone) sublingual tablets are white menthol-flavored tablets in an oval shape for the dosage strength 0.7 mg/0.18 mg, a triangular shape for the dosage strength 1.4 mg /0.36 mg, a D shape for the dosage strength 2.9 mg/0.71 mg, a round shape for the dosage strength 5.7 mg/1.4 mg, a diamond shape for the dosage strength 8.6 mg/2.1 mg and a capsule shape for the dosage strength 11.4 mg/2.9 mg. They are debossed with the respective dosage strength of buprenorphine. They contain buprenorphine HCl, an opioid partial agonist and naloxone HCl dihydrate, an opioid antagonist, at a ratio of 4:1 (ratio of free bases). ZUBSOLV is intended for sublingual administration and is available in six dosage strengths, 0.7 mg buprenorphine with 0.18 mg naloxone, 1.4 mg buprenorphine with 0.36 mg naloxone, 2.9 mg buprenorphine with 0.71 mg naloxone, 5.7 mg buprenorphine with 1.4 mg naloxone, 8.6 mg buprenorphine with 2.1 mg naloxone and 11.4 mg buprenorphine with 2.9 mg naloxone. Each sublingual tablet also contains mannitol, citric acid, sodium citrate, microcrystalline cellulose, croscarmellose sodium, sucralose, menthol, silicon dioxide and sodium stearyl fumarate and menthol flavor.      Chemically, buprenorphine HCl is (2S)-2-[17-(cyclopropylmethyl)-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14-ethano-14α-morphinan-7α-yl]-3,3-dimethylbutan-2-ol hydrochloride. It has the following chemical structure:<img alt=" It has the following chemical structure:Chemically, buprenorphine HCl is (2S)-2-[17-(cyclopropylmethyl)-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14-ethano-14α-morphinan-7α-yl]-3,3-dimethylbutan-2-ol hydrochloride." src="zubsolv-sublingual-tablets-01.jpg"/>      Buprenorphine HCl has the molecular formula C29 H41 NO4 • HCl and the molecular weight is 504.10. It is a white or off-white crystalline powder, sparingly soluble in water, freely soluble in methanol, soluble in alcohol, and practically insoluble in cyclohexane.      Chemically, naloxone HCl dihydrate is 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate. It has the following chemical structure:<img alt="It has the following chemical structure:Chemically, naloxone HCl dihydrate is 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate. " src="zubsolv-sublingual-tablets-02.jpg"/>      Naloxone HCl dihydrate has the molecular formula C19H21NO4 • HCl • 2H20 and the molecular weight is 399.87. It is a white to slightly off-white powder and is freely soluble in water, soluble in alcohol, and practically insoluble in toluene and ether.</section>

Zubsolv

buprenorphine 1.4 MG / naloxone 0.36 MG Sublingual Tablet

buprenorphine 1.4 MG / naloxone 0.36 MG Sublingual Tablet [Zubsolv]

buprenorphine 5.7 MG / naloxone 1.4 MG Sublingual Tablet

buprenorphine 5.7 MG / naloxone 1.4 MG Sublingual Tablet [Zubsolv]

buprenorphine 11.4 MG / naloxone 2.9 MG Sublingual Tablet

buprenorphine 11.4 MG / naloxone 2.9 MG Sublingual Tablet [Zubsolv]

buprenorphine 8.6 MG / naloxone 2.1 MG Sublingual Tablet

buprenorphine 8.6 MG / naloxone 2.1 MG Sublingual Tablet [Zubsolv]

buprenorphine 2.9 MG / naloxone 0.71 MG Sublingual Tablet

buprenorphine 2.9 MG / naloxone 0.71 MG Sublingual Tablet [Zubsolv]

buprenorphine

buprenorphine 0.7 MG / naloxone 0.18 MG Sublingual Tablet

buprenorphine 0.7 MG / naloxone 0.18 MG Sublingual Tablet [Zubsolv]

buprenorphine / naloxone

naloxone

Psoriasis (PsO)

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Ankylosing Spondylitis (AS)

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Taltz

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About Zubsolv 

Taking Zubsolv 

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Opioid Dependence Assessment Questionnaire 

Doctor Discussion Guide 