Kinase Inhibitors

Kinase Inhibitor

Cytochrome P450 3A Inhibitors

Leukemia, Lymphoid

Lymphoma, Non-Hodgkin

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Idelalisib is a kinase inhibitor. The chemical name for idelalisib is 5-fluoro-3-phenyl-2-[(1S)-1-(<span class="Italics">9H</span>-purin-6-ylamino)propyl]quinazolin-4(<span class="Italics">3H</span>)-one. It has a molecular formula of C22H18FN7O and a molecular weight of 415.42 g/mol. Idelalisib has the following structural formula:</p><div class="Figure"><img alt="Chemical Structure" src="zydelig-01.jpg"/></div><p>Idelalisib is a white to off-white solid with a pH-dependent aqueous solubility ranging from &lt;0.1 mg/mL at pH 5–7 to over 1 mg/mL at pH 2 under ambient conditions.</p><p>Zydelig (idelalisib) tablets are for oral use. Each tablet contains either 100 mg or 150 mg of idelalisib with the following inactive ingredients: microcrystalline cellulose, hydroxypropyl cellulose, croscarmellose sodium, sodium starch glycolate, magnesium stearate and a tablet coating. The tablet coating consists of polyethylene glycol, talc, polyvinyl alcohol, and titanium dioxide and of FD&amp;C Yellow #6/Sunset Yellow FCF Aluminum Lake (for the 100 mg tablet) and red iron oxide (for the 150 mg tablet).</p></section>

Zydelig

idelalisib

idelalisib 100 MG Oral Tablet

idelalisib 100 MG Oral Tablet [Zydelig]

idelalisib 150 MG Oral Tablet

idelalisib 150 MG Oral Tablet [Zydelig]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event

Prescribing Information

Medication Guide 

Submit MSL Request 

Pharmacy List

How To Order Zydelig

Coverage Authorization Request 

Coverage Authorization Appeal

Zyledig AccessConnect Enrollment Form

Quick Start Program

Patient Assistance Program 

Enroll in Patient Savings Program 

Zyledig Support Program 

Instructions For Use: Chronic Lymphocytic Leukemia (CLL)