| Acne Vulgaris
Aczone vs Aklief
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Aczone vs Aklief with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAklief has a higher rate of injection site reactions vs Aczone based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Aklief but not Aczone, including UnitedHealthcare
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Category
Aczone
Aklief
At A Glance
Topical
Daily
Sulfone
Topical
Once daily
Retinoid (RAR agonist)
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply approximately a pea-sized amount of ACZONE Gel, 7.5% in a thin layer to the entire face once daily; a thin layer may also be applied to other affected areas once daily.
Acne Vulgaris Apply a thin layer once daily in the evening to clean, dry skin; one pump actuation for the face, two for the upper trunk, with an optional additional actuation for the middle and lower back; avoid contact with eyes, lips, paranasal creases, and mucous membranes.
Contraindications
—
—
Adverse Reactions
Most common (>=0.9%) Application site dryness, application site pruritus
Serious Agranulocytosis, hemolytic anemia, peripheral neuropathy, toxic epidermal necrolysis, erythema multiforme, bullous and exfoliative dermatitis, erythema nodosum, urticaria (reported with oral use of dapsone)
Postmarketing Methemoglobinemia, rash (including erythematous rash, application site rash), swelling of face (including lip swelling, eye swelling)
Most common (>=1%) Application site irritation, application site pruritus, sunburn
Pharmacology
Dapsone is a sulfone whose mechanism of action in treating acne vulgaris is not known; topical application results in minimal systemic absorption.
Trifarotene is a retinoic acid receptor (RAR) agonist with particular activity at the gamma subtype; stimulation of RAR modulates target genes associated with cell differentiation and inflammation.
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Most Common Insurance
Anthem BCBS
Aczone
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (9/12)
Aklief
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Aczone
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Aklief
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (4/8)
Humana
Aczone
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Aklief
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Aczone.
No savings programs available for Aklief.
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AczoneView full Aczone profile
AkliefView full Aklief profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.