| Acne Vulgaris
Aczone vs Onexton
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Aczone vs Onexton with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsOnexton has a higher rate of injection site reactions vs Aczone based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Onexton but not Aczone, including UnitedHealthcare
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Category
Aczone
Onexton
At A Glance
Topical
Daily
Sulfone
Topical
Once daily
Antibiotic/keratolytic combination
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply approximately a pea-sized amount of ACZONE Gel, 7.5% in a thin layer to the entire face once daily; a thin layer may also be applied to other affected areas once daily.
Acne Vulgaris Apply a pea-sized amount to the face once daily; wash face gently with mild soap, rinse with warm water, and pat dry before applying. Avoid eyes, mouth, mucous membranes, and areas of broken skin.
Contraindications
—
- Hypersensitivity (e.g., anaphylaxis) to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
Adverse Reactions
Most common (>=0.9%) Application site dryness, application site pruritus
Serious Agranulocytosis, hemolytic anemia, peripheral neuropathy, toxic epidermal necrolysis, erythema multiforme, bullous and exfoliative dermatitis, erythema nodosum, urticaria (reported with oral use of dapsone)
Postmarketing Methemoglobinemia, rash (including erythematous rash, application site rash), swelling of face (including lip swelling, eye swelling)
Most common (<0.5%) Burning sensation, contact dermatitis, pruritus, rash
Postmarketing Anaphylaxis, allergic reactions leading to hospitalization
Pharmacology
Dapsone is a sulfone whose mechanism of action in treating acne vulgaris is not known; topical application results in minimal systemic absorption.
Clindamycin is a lincosamide antibacterial that binds to the 50S ribosomal subunit of susceptible bacteria and suppresses protein synthesis by interfering with peptidyl transfer; benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects, though its precise mechanism is unknown.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Aczone
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (9/12)
Onexton
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Aczone
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Onexton
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Aczone
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Onexton
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Aczone.
No savings programs available for Onexton.
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AczoneView full Aczone profile
OnextonView full Onexton profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.