| Acne Vulgaris
Aczone vs Winlevi
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Aczone vs Winlevi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsWinlevi has a higher rate of injection site reactions vs Aczone based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Winlevi but not Aczone, including UnitedHealthcare
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Category
Aczone
Winlevi
At A Glance
Topical
Daily
Sulfone
Topical
Twice daily
Androgen receptor inhibitor
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply approximately a pea-sized amount of ACZONE Gel, 7.5% in a thin layer to the entire face once daily; a thin layer may also be applied to other affected areas once daily.
Acne Vulgaris Apply a thin uniform layer twice daily (morning and evening) to the affected area after gently cleansing and drying the skin; for topical use only.
Contraindications
—
—
Adverse Reactions
Most common (>=0.9%) Application site dryness, application site pruritus
Serious Agranulocytosis, hemolytic anemia, peripheral neuropathy, toxic epidermal necrolysis, erythema multiforme, bullous and exfoliative dermatitis, erythema nodosum, urticaria (reported with oral use of dapsone)
Postmarketing Methemoglobinemia, rash (including erythematous rash, application site rash), swelling of face (including lip swelling, eye swelling)
Most common (>=7%) erythema/redness, pruritus, scaling/dryness
Other edema, stinging/burning, skin atrophy, striae rubrae, telangiectasia, hyperkalemia, polycystic ovaries, amenorrhea
Pharmacology
Dapsone is a sulfone whose mechanism of action in treating acne vulgaris is not known; topical application results in minimal systemic absorption.
Clascoterone is an androgen receptor inhibitor; the exact mechanism of action of WINLEVI cream for the topical treatment of acne vulgaris is unknown.
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Most Common Insurance
Anthem BCBS
Aczone
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (9/12)
Winlevi
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Aczone
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Winlevi
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Aczone
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Winlevi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Aczone.
No savings programs available for Winlevi.
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AczoneView full Aczone profile
WinleviView full Winlevi profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.