| Acne Vulgaris
Amzeeq vs Onexton
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Amzeeq vs Onexton with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsOnexton has a higher rate of injection site reactions vs Amzeeq based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Onexton but not Amzeeq, including UnitedHealthcare
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Category
Amzeeq
Onexton
At A Glance
Topical
Daily
Tetracycline antibiotic
Topical
Once daily
Antibiotic/keratolytic combination
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply a small (cherry-sized) amount of foam to acne-affected areas of the face and body once daily, at least 1 hour before bedtime; do not bathe, shower, or swim for at least 1 hour after application.
Acne Vulgaris Apply a pea-sized amount to the face once daily; wash face gently with mild soap, rinse with warm water, and pat dry before applying. Avoid eyes, mouth, mucous membranes, and areas of broken skin.
Contraindications
- Hypersensitivity to any tetracycline or any other ingredient in AMZEEQ
- Hypersensitivity (e.g., anaphylaxis) to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
Adverse Reactions
Most common (>=1%) Headache
Most common (<0.5%) Burning sensation, contact dermatitis, pruritus, rash
Postmarketing Anaphylaxis, allergic reactions leading to hospitalization
Pharmacology
Tetracycline-class antibiotic; the mechanism of action of AMZEEQ for treatment of acne is unknown, though minocycline is active in vitro against most isolates of Propionibacterium acnes.
Clindamycin is a lincosamide antibacterial that binds to the 50S ribosomal subunit of susceptible bacteria and suppresses protein synthesis by interfering with peptidyl transfer; benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects, though its precise mechanism is unknown.
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Most Common Insurance
Anthem BCBS
Amzeeq
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Onexton
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Amzeeq
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Onexton
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Amzeeq
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
Onexton
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Amzeeq.
No savings programs available for Onexton.
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AmzeeqView full Amzeeq profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.