| Acne Vulgaris

Amzeeq vs Tazorac

Side-by-side clinical, coverage, and cost comparison for acne vulgaris.
Deep comparison between: Amzeeq vs Tazorac with Prescriber.AI
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Safety signalsTazorac has a higher rate of injection site reactions vs Amzeeq based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tazorac but not Amzeeq, including UnitedHealthcare
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Amzeeq
Tazorac
At A Glance
Topical
Daily
Tetracycline antibiotic
Topical
Daily
Retinoid
Indications
  • Acne Vulgaris
  • Psoriasis vulgaris
  • Acne Vulgaris
Dosing
Acne Vulgaris Apply a small (cherry-sized) amount of foam to acne-affected areas of the face and body once daily, at least 1 hour before bedtime; do not bathe, shower, or swim for at least 1 hour after application.
Psoriasis vulgaris Apply a thin film (2 mg/cm2) of 0.05% cream once daily in the evening to psoriatic lesions only; increase to 0.1% if tolerated and medically indicated.
Acne Vulgaris Apply a thin layer (2 mg/cm2) of 0.1% cream once daily in the evening to affected facial skin areas after gentle cleansing and drying.
Contraindications
  • Hypersensitivity to any tetracycline or any other ingredient in AMZEEQ
  • Pregnancy (retinoids may cause fetal harm)
  • Known hypersensitivity to any component of TAZORAC Cream
Adverse Reactions
Most common (>=1%) Headache
Most common (>=10%) Psoriasis: pruritus, erythema, burning; Acne: desquamation, dry skin, erythema, burning sensation
Serious Embryofetal toxicity, photosensitivity and risk of sunburn
Postmarketing Blister, dermatitis, urticaria, skin exfoliation, skin discoloration (hyperpigmentation or hypopigmentation), swelling at or near application sites, pain
Pharmacology
Tetracycline-class antibiotic; the mechanism of action of AMZEEQ for treatment of acne is unknown, though minocycline is active in vitro against most isolates of Propionibacterium acnes.
Tazarotene is a retinoid prodrug converted by esterase hydrolysis to tazarotenic acid, which binds retinoic acid receptors RAR-beta and RAR-gamma with relative selectivity and may modify gene expression in psoriatic and acne-affected skin.
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Most Common Insurance
Anthem BCBS
Amzeeq
  • Covered on 5 commercial plans
  • PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
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No coverage data available for Tazorac.
UnitedHealthcare
Amzeeq
  • Covered on 4 commercial plans
  • PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
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No coverage data available for Tazorac.
Humana
Amzeeq
  • Covered on 0 commercial plans
  • PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
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No coverage data available for Tazorac.
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Amzeeq.
No savings programs available for Tazorac.
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AmzeeqView full Amzeeq profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.