| Acne Vulgaris
Doryx MPC vs Seysara
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Doryx Mpc vs Seysara with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSeysara has a higher rate of injection site reactions vs Doryx Mpc based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Seysara but not Doryx Mpc, including UnitedHealthcare
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Category
Doryx Mpc
Seysara
At A Glance
Oral
Once or twice daily
Tetracycline antibiotic
Oral
Daily
Tetracycline-class antibiotic
Indications
- Rocky Mountain Spotted Fever
- TYPHUS
- Q Fever
- Rickettsialpox
- non-gonococcal urethritis (NGU)
- Lymphogranuloma Venereum
- Granuloma Inguinale
- Gonorrhea
- Chancroid
- Psittacosis
- Respiratory Tract Infections
- Upper Respiratory Infections
- Relapsing Fever
- Plague
- Tularemia
- Cholera
- Brucellosis
- Bartonella Infections
- Trachoma
- Inclusion conjunctivitis
- Anthrax disease
- Syphilis
- Yaws
- Listeriosis
- Necrotizing Ulcerative Gingivitis
- Actinomycosis
- Amebiasis
- Acne Vulgaris
- Malaria
- Urethritis
- Uterine Cervicitis
- Proctitis
- Urinary tract infection
- Acne Vulgaris
Dosing
Rocky Mountain Spotted Fever, TYPHUS, Q Fever, Rickettsialpox, Relapsing Fever, Plague, Tularemia, Cholera, Brucellosis, Bartonella Infections, Psittacosis, Respiratory Tract Infections, Upper Respiratory Infections, Trachoma, Inclusion conjunctivitis, Yaws, Listeriosis, Necrotizing Ulcerative Gingivitis, Actinomycosis, Amebiasis, Acne Vulgaris, Urinary tract infection Adults: 240 mg on day 1 (120 mg every 12 hours), then 120 mg daily maintenance; for severe infections (e.g., chronic urinary tract infections), 120 mg every 12 hours. Pediatric <45 kg (>8 years, less severe disease): 5.3 mg/kg divided in 2 doses on day 1, then 2.6 mg/kg daily; severe or life-threatening infections: 2.6 mg/kg every 12 hours. Pediatric >=45 kg: adult dose.
non-gonococcal urethritis (NGU), Urethritis, Uterine Cervicitis, Proctitis 120 mg orally twice daily for 7 days.
Gonorrhea 120 mg orally twice daily for 7 days; alternate single-visit dose: 360 mg followed in 1 hour by a second 360 mg dose.
Syphilis (early, penicillin allergy) 120 mg orally twice daily for 2 weeks.
Syphilis (>1 year duration, penicillin allergy) 120 mg orally twice daily for 4 weeks.
Anthrax disease Adults: 120 mg orally twice daily for 60 days. Pediatric <45 kg: 2.6 mg/kg orally twice daily for 60 days; >=45 kg: adult dose.
Malaria Adults: 120 mg once daily. Pediatric >=8 years: 2.4 mg/kg once daily; >=45 kg: adult dose. Begin 1-2 days before travel, continue during travel, and for 4 weeks after leaving the malarious area.
Acne Vulgaris Weight-based once-daily oral dosing: 60 mg (33-54 kg), 100 mg (55-84 kg), or 150 mg (85-136 kg); take with or without food and adequate fluid; reassess if no improvement after 12 weeks.
Contraindications
- Hypersensitivity to any of the tetracyclines
- Hypersensitivity to any tetracycline
Adverse Reactions
Gastrointestinal Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, pancreatitis, esophagitis, esophageal ulcerations
Skin Maculopapular rashes, erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, fixed drug eruption, photosensitivity
Hypersensitivity Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus
Hematologic Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia
Neurologic/Psychiatric Intracranial hypertension (pseudotumor cerebri), depression, anxiety, suicidal ideation, insomnia, abnormal dreams, hallucination
Renal Rise in BUN (dose-related)
Thyroid Brown-black microscopic discoloration of thyroid glands with prolonged use; no known thyroid function abnormalities
Most common (>=1%) Nausea
Less common (<1%, female subjects) Vulvovaginal mycotic infection, vulvovaginal candidiasis
Pharmacology
Doxycycline is a tetracycline-class antimicrobial that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, exerting bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria.
Sarecycline is an aminomethylcycline within the tetracycline class that binds to the 30S ribosomal subunit and blocks protein synthesis in Propionibacterium acnes; its precise mechanism for treating the inflammatory lesions of non-nodular acne vulgaris is not known.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Doryx Mpc
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (0/12)
Seysara
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Doryx Mpc
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (0/8)
Seysara
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Doryx Mpc
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Seysara
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Doryx Mpc.
No savings programs available for Seysara.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.