| Acne Vulgaris
Doryx MPC vs Tazorac
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Doryx Mpc vs Tazorac with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTazorac has a higher rate of injection site reactions vs Doryx Mpc based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tazorac but not Doryx Mpc, including UnitedHealthcare
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Category
Doryx Mpc
Tazorac
At A Glance
Oral
Once or twice daily
Tetracycline antibiotic
Topical
Daily
Retinoid
Indications
- Rocky Mountain Spotted Fever
- TYPHUS
- Q Fever
- Rickettsialpox
- non-gonococcal urethritis (NGU)
- Lymphogranuloma Venereum
- Granuloma Inguinale
- Gonorrhea
- Chancroid
- Psittacosis
- Respiratory Tract Infections
- Upper Respiratory Infections
- Relapsing Fever
- Plague
- Tularemia
- Cholera
- Brucellosis
- Bartonella Infections
- Trachoma
- Inclusion conjunctivitis
- Anthrax disease
- Syphilis
- Yaws
- Listeriosis
- Necrotizing Ulcerative Gingivitis
- Actinomycosis
- Amebiasis
- Acne Vulgaris
- Malaria
- Urethritis
- Uterine Cervicitis
- Proctitis
- Urinary tract infection
- Psoriasis vulgaris
- Acne Vulgaris
Dosing
Rocky Mountain Spotted Fever, TYPHUS, Q Fever, Rickettsialpox, Relapsing Fever, Plague, Tularemia, Cholera, Brucellosis, Bartonella Infections, Psittacosis, Respiratory Tract Infections, Upper Respiratory Infections, Trachoma, Inclusion conjunctivitis, Yaws, Listeriosis, Necrotizing Ulcerative Gingivitis, Actinomycosis, Amebiasis, Acne Vulgaris, Urinary tract infection Adults: 240 mg on day 1 (120 mg every 12 hours), then 120 mg daily maintenance; for severe infections (e.g., chronic urinary tract infections), 120 mg every 12 hours. Pediatric <45 kg (>8 years, less severe disease): 5.3 mg/kg divided in 2 doses on day 1, then 2.6 mg/kg daily; severe or life-threatening infections: 2.6 mg/kg every 12 hours. Pediatric >=45 kg: adult dose.
non-gonococcal urethritis (NGU), Urethritis, Uterine Cervicitis, Proctitis 120 mg orally twice daily for 7 days.
Gonorrhea 120 mg orally twice daily for 7 days; alternate single-visit dose: 360 mg followed in 1 hour by a second 360 mg dose.
Syphilis (early, penicillin allergy) 120 mg orally twice daily for 2 weeks.
Syphilis (>1 year duration, penicillin allergy) 120 mg orally twice daily for 4 weeks.
Anthrax disease Adults: 120 mg orally twice daily for 60 days. Pediatric <45 kg: 2.6 mg/kg orally twice daily for 60 days; >=45 kg: adult dose.
Malaria Adults: 120 mg once daily. Pediatric >=8 years: 2.4 mg/kg once daily; >=45 kg: adult dose. Begin 1-2 days before travel, continue during travel, and for 4 weeks after leaving the malarious area.
Psoriasis vulgaris Apply a thin film (2 mg/cm2) of 0.05% cream once daily in the evening to psoriatic lesions only; increase to 0.1% if tolerated and medically indicated.
Acne Vulgaris Apply a thin layer (2 mg/cm2) of 0.1% cream once daily in the evening to affected facial skin areas after gentle cleansing and drying.
Contraindications
- Hypersensitivity to any of the tetracyclines
- Pregnancy (retinoids may cause fetal harm)
- Known hypersensitivity to any component of TAZORAC Cream
Adverse Reactions
Gastrointestinal Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, pancreatitis, esophagitis, esophageal ulcerations
Skin Maculopapular rashes, erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, fixed drug eruption, photosensitivity
Hypersensitivity Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus
Hematologic Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia
Neurologic/Psychiatric Intracranial hypertension (pseudotumor cerebri), depression, anxiety, suicidal ideation, insomnia, abnormal dreams, hallucination
Renal Rise in BUN (dose-related)
Thyroid Brown-black microscopic discoloration of thyroid glands with prolonged use; no known thyroid function abnormalities
Most common (>=10%) Psoriasis: pruritus, erythema, burning; Acne: desquamation, dry skin, erythema, burning sensation
Serious Embryofetal toxicity, photosensitivity and risk of sunburn
Postmarketing Blister, dermatitis, urticaria, skin exfoliation, skin discoloration (hyperpigmentation or hypopigmentation), swelling at or near application sites, pain
Pharmacology
Doxycycline is a tetracycline-class antimicrobial that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, exerting bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria.
Tazarotene is a retinoid prodrug converted by esterase hydrolysis to tazarotenic acid, which binds retinoic acid receptors RAR-beta and RAR-gamma with relative selectivity and may modify gene expression in psoriatic and acne-affected skin.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Doryx Mpc
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (0/12)
No coverage data available for Tazorac.
UnitedHealthcare
Doryx Mpc
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (0/8)
No coverage data available for Tazorac.
Humana
Doryx Mpc
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
No coverage data available for Tazorac.
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Doryx Mpc.
No savings programs available for Tazorac.
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Doryx MpcView full Doryx Mpc profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.