| Acne Vulgaris
Epiduo Forte vs Onexton
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Epiduo vs Onexton with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsOnexton has a higher rate of injection site reactions vs Epiduo based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Onexton but not Epiduo, including UnitedHealthcare
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Category
Epiduo
Onexton
At A Glance
Topical
Daily
Retinoid + benzoyl peroxide combination
Topical
Once daily
Antibiotic/keratolytic combination
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply a thin film once daily after washing to affected areas of the face and/or trunk; use a pea-sized amount for each area of the face.
Acne Vulgaris Apply a pea-sized amount to the face once daily; wash face gently with mild soap, rinse with warm water, and pat dry before applying. Avoid eyes, mouth, mucous membranes, and areas of broken skin.
Contraindications
—
- Hypersensitivity (e.g., anaphylaxis) to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
Adverse Reactions
Most common (>=1%) Dry skin, contact dermatitis, application site burning, application site irritation, skin irritation
Postmarketing Eyelid edema, sunburn, blister, pain of skin, pruritus, swelling face, conjunctivitis, skin discoloration, rash, eczema, throat tightness, allergic contact dermatitis
Most common (<0.5%) Burning sensation, contact dermatitis, pruritus, rash
Postmarketing Anaphylaxis, allergic reactions leading to hospitalization
Pharmacology
Adapalene is a retinoid that modulates cellular differentiation, keratinization, and inflammatory processes; benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects.
Clindamycin is a lincosamide antibacterial that binds to the 50S ribosomal subunit of susceptible bacteria and suppresses protein synthesis by interfering with peptidyl transfer; benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects, though its precise mechanism is unknown.
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Most Common Insurance
Anthem BCBS
Epiduo
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Onexton
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Epiduo
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (5/8)
Onexton
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Epiduo
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Onexton
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Epiduo.
No savings programs available for Onexton.
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EpiduoView full Epiduo profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.