| Acne Vulgaris
Onexton vs Seysara
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Onexton vs Seysara with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSeysara has a higher rate of injection site reactions vs Onexton based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Seysara but not Onexton, including UnitedHealthcare
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Category
Onexton
Seysara
At A Glance
Topical
Once daily
Antibiotic/keratolytic combination
Oral
Daily
Tetracycline-class antibiotic
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply a pea-sized amount to the face once daily; wash face gently with mild soap, rinse with warm water, and pat dry before applying. Avoid eyes, mouth, mucous membranes, and areas of broken skin.
Acne Vulgaris Weight-based once-daily oral dosing: 60 mg (33-54 kg), 100 mg (55-84 kg), or 150 mg (85-136 kg); take with or without food and adequate fluid; reassess if no improvement after 12 weeks.
Contraindications
- Hypersensitivity (e.g., anaphylaxis) to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
- Hypersensitivity to any tetracycline
Adverse Reactions
Most common (<0.5%) Burning sensation, contact dermatitis, pruritus, rash
Postmarketing Anaphylaxis, allergic reactions leading to hospitalization
Most common (>=1%) Nausea
Less common (<1%, female subjects) Vulvovaginal mycotic infection, vulvovaginal candidiasis
Pharmacology
Clindamycin is a lincosamide antibacterial that binds to the 50S ribosomal subunit of susceptible bacteria and suppresses protein synthesis by interfering with peptidyl transfer; benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects, though its precise mechanism is unknown.
Sarecycline is an aminomethylcycline within the tetracycline class that binds to the 30S ribosomal subunit and blocks protein synthesis in Propionibacterium acnes; its precise mechanism for treating the inflammatory lesions of non-nodular acne vulgaris is not known.
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Most Common Insurance
Anthem BCBS
Onexton
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Seysara
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Onexton
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Seysara
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Onexton
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Seysara
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Onexton.
No savings programs available for Seysara.
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OnextonView full Onexton profile
SeysaraView full Seysara profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.