| Acne Vulgaris
Onexton vs Tazorac
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Onexton vs Tazorac with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTazorac has a higher rate of injection site reactions vs Onexton based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tazorac but not Onexton, including UnitedHealthcare
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Category
Onexton
Tazorac
At A Glance
Topical
Once daily
Antibiotic/keratolytic combination
Topical
Daily
Retinoid
Indications
- Acne Vulgaris
- Psoriasis vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply a pea-sized amount to the face once daily; wash face gently with mild soap, rinse with warm water, and pat dry before applying. Avoid eyes, mouth, mucous membranes, and areas of broken skin.
Psoriasis vulgaris Apply a thin film (2 mg/cm2) of 0.05% cream once daily in the evening to psoriatic lesions only; increase to 0.1% if tolerated and medically indicated.
Acne Vulgaris Apply a thin layer (2 mg/cm2) of 0.1% cream once daily in the evening to affected facial skin areas after gentle cleansing and drying.
Contraindications
- Hypersensitivity (e.g., anaphylaxis) to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
- Pregnancy (retinoids may cause fetal harm)
- Known hypersensitivity to any component of TAZORAC Cream
Adverse Reactions
Most common (<0.5%) Burning sensation, contact dermatitis, pruritus, rash
Postmarketing Anaphylaxis, allergic reactions leading to hospitalization
Most common (>=10%) Psoriasis: pruritus, erythema, burning; Acne: desquamation, dry skin, erythema, burning sensation
Serious Embryofetal toxicity, photosensitivity and risk of sunburn
Postmarketing Blister, dermatitis, urticaria, skin exfoliation, skin discoloration (hyperpigmentation or hypopigmentation), swelling at or near application sites, pain
Pharmacology
Clindamycin is a lincosamide antibacterial that binds to the 50S ribosomal subunit of susceptible bacteria and suppresses protein synthesis by interfering with peptidyl transfer; benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects, though its precise mechanism is unknown.
Tazarotene is a retinoid prodrug converted by esterase hydrolysis to tazarotenic acid, which binds retinoic acid receptors RAR-beta and RAR-gamma with relative selectivity and may modify gene expression in psoriatic and acne-affected skin.
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Most Common Insurance
Anthem BCBS
Onexton
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
No coverage data available for Tazorac.
UnitedHealthcare
Onexton
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
No coverage data available for Tazorac.
Humana
Onexton
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
No coverage data available for Tazorac.
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Onexton.
No savings programs available for Tazorac.
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OnextonView full Onexton profile
TazoracView full Tazorac profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.