| Acne Vulgaris
Onexton vs Winlevi
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Onexton vs Winlevi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsWinlevi has a higher rate of injection site reactions vs Onexton based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Winlevi but not Onexton, including UnitedHealthcare
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Category
Onexton
Winlevi
At A Glance
Topical
Once daily
Antibiotic/keratolytic combination
Topical
Twice daily
Androgen receptor inhibitor
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply a pea-sized amount to the face once daily; wash face gently with mild soap, rinse with warm water, and pat dry before applying. Avoid eyes, mouth, mucous membranes, and areas of broken skin.
Acne Vulgaris Apply a thin uniform layer twice daily (morning and evening) to the affected area after gently cleansing and drying the skin; for topical use only.
Contraindications
- Hypersensitivity (e.g., anaphylaxis) to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
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Adverse Reactions
Most common (<0.5%) Burning sensation, contact dermatitis, pruritus, rash
Postmarketing Anaphylaxis, allergic reactions leading to hospitalization
Most common (>=7%) erythema/redness, pruritus, scaling/dryness
Other edema, stinging/burning, skin atrophy, striae rubrae, telangiectasia, hyperkalemia, polycystic ovaries, amenorrhea
Pharmacology
Clindamycin is a lincosamide antibacterial that binds to the 50S ribosomal subunit of susceptible bacteria and suppresses protein synthesis by interfering with peptidyl transfer; benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects, though its precise mechanism is unknown.
Clascoterone is an androgen receptor inhibitor; the exact mechanism of action of WINLEVI cream for the topical treatment of acne vulgaris is unknown.
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Most Common Insurance
Anthem BCBS
Onexton
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Winlevi
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Onexton
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Winlevi
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Onexton
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Winlevi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Onexton.
No savings programs available for Winlevi.
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OnextonView full Onexton profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.