| Acne Vulgaris
Seysara vs Winlevi
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Seysara vs Winlevi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsWinlevi has a higher rate of injection site reactions vs Seysara based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Winlevi but not Seysara, including UnitedHealthcare
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Category
Seysara
Winlevi
At A Glance
Oral
Daily
Tetracycline-class antibiotic
Topical
Twice daily
Androgen receptor inhibitor
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Weight-based once-daily oral dosing: 60 mg (33-54 kg), 100 mg (55-84 kg), or 150 mg (85-136 kg); take with or without food and adequate fluid; reassess if no improvement after 12 weeks.
Acne Vulgaris Apply a thin uniform layer twice daily (morning and evening) to the affected area after gently cleansing and drying the skin; for topical use only.
Contraindications
- Hypersensitivity to any tetracycline
—
Adverse Reactions
Most common (>=1%) Nausea
Less common (<1%, female subjects) Vulvovaginal mycotic infection, vulvovaginal candidiasis
Most common (>=7%) erythema/redness, pruritus, scaling/dryness
Other edema, stinging/burning, skin atrophy, striae rubrae, telangiectasia, hyperkalemia, polycystic ovaries, amenorrhea
Pharmacology
Sarecycline is an aminomethylcycline within the tetracycline class that binds to the 30S ribosomal subunit and blocks protein synthesis in Propionibacterium acnes; its precise mechanism for treating the inflammatory lesions of non-nodular acne vulgaris is not known.
Clascoterone is an androgen receptor inhibitor; the exact mechanism of action of WINLEVI cream for the topical treatment of acne vulgaris is unknown.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Seysara
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (9/12)
Winlevi
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Seysara
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Winlevi
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Seysara
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (2/3)
Winlevi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Seysara.
No savings programs available for Winlevi.
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SeysaraView full Seysara profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.